Boosting longevity is a function of many different attributes. Key among these are activating longevity genes (SIRT1 and FOXO) and decreasing levels of oxidative stress.
ACTIVATING LONGEVITY GENES -
BILBERRY ANTHOCYANINS (Blue Color)
GRAPE SEED EXTRACT (GSE) (5-8)
N-ACETYLCYSTEINE (GLUTATHIONE BOOSTER) (9-11)
(1) Li Y, et al. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors. 2018 Jan.
(2) Scerbak C, et al. Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons. Geroscience. 2018 Apr.
(3) Ryyti R, et al. Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity. PLoS One. 2020 May.
(4) Li J, et al. Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats. J Agric Food Chem. 2019 Jul.
(5) Mas-Capdevila A, et al. Changes in arterial blood pressure caused by long-term administration of grape seed proanthocyanidins in rats with established hypertension. Food Funct. 2020 Oct.
(6) Ruan Y, et al. Grape Seed Proanthocyanidin Extract Ameliorates Cardiac Remodelling After Myocardial Infarction Through PI3K/AKT Pathway in Mice. Front Pharmacol. 2020 Dec.
(7) Kadri S, et al. Protective effect of grape seed extract and orlistat co-treatment against stroke: Effect on oxidative stress and energy failure. Biomed Pharmacother. 2021 Apr.
(8) Kijima K, et al. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun.
(9) Niraula P, et al. N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression. Biogerontology. 2019 Aug.
(10) McCarty M, et al. Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. Adv Nutr. 2021 Mar.
(11) DiNicolantonio J, et al. Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1β signalling: a potential strategy for preventing cardiovascular events? Open Heart. 2017 Jul.
Natural berries are among the richest sources of bioactive compounds (1-2), which play significant roles in health maintenance, including as antioxidants, anti-inflammation, cardiovascular, eye and brain. Anthocyanins, which provide the distinctive colors of berries (reds, purple, blues), are among the most effective bioactives for the promotion of health.
A very important anthocyanin is C3G (Cyanidin-3-O-glucoside). Besides the beneficial health effects in the eyes and cardiovascular system, research has linked C3G to longevity. Using C. elegans as the experimental organism model, high percentage C3G purple anthocyanin extracts extended mean lifespans by 10%. (3) The mechanism involved with life extension involved the activation of the FOXO transcription factor analog (DAF16). FOXO is the transcription factor associated with extreme lifespan. Also noted in the study with c. elegans was significant decreases in oxidative stress and an increase in response to stress.
The myriad of bioactive compounds in berries include phenolic compunds (phenolic acids, flavonoids, (such as anthocyanins and flavonols, and tannins) and ascorbic acid. (1)
Since there are variations in the distribution of bioactives among the different types of berries, a mix of berries, including high content C3G, will provide the maximum health benefits.
(1) Skrovankova S, et al. Bioactive Compounds and Antioxidant Activity in Different Types of Berries.
Int J Mol Sci. 2015 Oct
(2) Manganaris GA, et al. Berry antioxidants: small fruits providing large benefits. J Sci Food Agric. 2014 Mar 30
(3) Chen W, et al. Anthocyanin-rich purple wheat prolongs the life span of Caenorhabditis elegans probably by activating the DAF-16/FOXO transcription factor. J Agric Food Chem. 2013 Mar.