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VASCULAR VX™ - Support for Vascular Health

Vascular health is associated with healthy endothelium, the lining which compose the arteries and maintains blood flow. When healthy blood flow is maintained, tissues and organs of the body receive oxygenated blood with anti-aging nutrients.

Important factors of healthy blood flow:

• Vascular Endothelium - . Aging causes dysfunction (including inflammation) of the lining of the arteries (the endothelium). As a result arteries become stiffened and less functional. 

• Aronia berry - Inhibits inflammatory TNF- α induced inflammation of the arterial lining., including suppression of vascular cell adhesion molecule-1. These effects are  anti-atherosclerotic, and help maintain younger arterial function.(1)  Further, administration of aronia berry was shown acute improvement of flow-mediated dilation (FMD), arterial stiffness, blood pressure and  heart rate in male subjects.(2)
• Apigenin - Restores arterial function in aging by mitigating endothelial stiffening, inflammation and oxidative stress.(3)
• Saffron - Induces endothelium relaxation via two mechanisms: Via nitric oxide synthesis and effect on vascular smooth muscle,(4) Also saffron inhibits vascular inflammation.(5)
• Cynara scolymus (Artichoke) - Regulates nitric oxide synthase in support of endothelium relaxation.(6) A study of heart disease in Spain demonstrated an association of decreased mortality due to cardiovascular diseases and cynara scolymus consumption.(7)

 VASCULAR VX™ (Aronia berry | Apigenin | Saffron |Cynara scolymus)

REFERENCES:

(1) Iwoshima T, et al.  Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3. Food Nutr Res, 2019.

(2) Istas G, et al. Effects of aronia berry (poly)phenols on vascular function and gut microbiota: a double-blind randomized controlled trial in adult men. Am J Clin Nutr. 2019

 (3) Clayton Z, et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021

(4) Rzavi B, et al. Saffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms. Iran J Pharm Res. Summer 2018.

(5) Song L, et al. Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells. Cell Physiol Biochem. 2016

(6) Li H, et al. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. J Pharmacol Exp Ther. 2004.

(7) Amendo-Pena A, et al. Production of Vegetables and Artichokes Is Associated with Lower Cardiovascular Mortality: An Ecological Study. Int J environ Res Public Health. 2020

Saffron - Cardiovascular Benefits

Cardiovascular disease is a significant causative factor in mortality. Saffron has important anti-aging benefits including improvement of cardiovascular health. The bioactive constituents of saffron (Crocin and Crocetin) play major roles in cardiovascular fitness.

Significantly, saffron may therapeutically provide cardiovascular benefits in the following manner: (1)

• Hypertension / Blood Pressure.- Studies indicate that saffron may lower diastolic blood pressure. Much of this involved relaxation of blood vessels. Further saffron may increase nitric oxide levels, which also promote lowering of blood pressure.
• Inhibit LDL Cholesterol Oxidation -  As a potent antioxidant, saffron has been shown to inhibit LDL oxidation. Oxidized LDL is a component of atherosclerotic plaques.
• Inhibits Foam Cell Formation - Macrophage foam cell formation is a critical stage in the development of atherosclerosis. Active saffron components crocin and crocetin inhibit foam cells from developing.
• Inhibits Vascular Cell Adhesion Molecule-1 (VCAM-1) - Another important factor in atherosclerosis development. Again, VCAM-1 is suppressed by crocin and crocetin.

VASCULAR VX™  (Includes Saffron with Crocin and Crocetin)

REFERENCES:

(1) Roshanravan N, et al. The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials. Phytother Res. 2022 Jan

Meso Zeaxanthin and Vitamin D - May counter Age-Related Macular Degeneration (AMD)

Age Related Macular Degeneration (AMD) is characterized by retinal inflammation and oxidative stress. Chronic degeneration of the retina is related to the unbated toxic pathologies of these stressors. Lab research, using human retinal pigmented epithelium cells, indicates that the combination of Vitamin D and Meso Zeaxanthin, may provide value to early stage AMD.(1)

VISION VITALITY (20mg of Meso Zeaxanthin per dose)

REFERENCES:

(1) Lazzara F, et al. Effects of Vitamin D ₃ and Meso-Zeaxanthin on Human Retinal Pigmented Epithelial Cells in Three Integrated in vitro Paradigms of Age-Related Macular Degeneration. Front Phramacol. 2021 Nov.

Cardiovascular Health -Restoring Arterial Health

Maintaining healthy arteries promotes blood circulation, tissue and organ oxygenation and longer life

VASCULAR VX™ is a next generation vascular support formula, helping to maintain arterial elasticity, and limiting potential for the pathological build-up in the arteries, which is responsible for atherosclerosis.

• ARONIA BERRY (Polysaccharides) - Ameliorates aging and inflammation in research animals, via beneficial support of anti-aging signaling pathways AMPK/SIRT1/NF-κB and Nrf2/HO-1. Significantly, aronia berry increases levels of beneficial bacteria in the intestine which plays an important anti-aging role. (1)
• Increases in HDL cholesterol in aging lab animals.(2)
• Provides comprehensive cardiovascular support. Many studies have shown the efficacy of aronia berry in in vitro and in vivo for cardiovascular health. Indications include beneficial effects on  hypertension, LDL oxidation, lipid peroxidation, total plasma antioxidant capacity and dyslipidemia.(3)
• SAFFRON -  Studies indicate that saffron may have a anti-atherosclerosis role. Important saffron benefits may include atherosclerosis regression and /or stabilization of atherosclerosis in animal models prone to atherosclerosis.(4)  Also clinical studies show positive effects in support of blood circulation.(5) 
• ARTICHOKE - Supports healthy lipid levels. Including decreased LDL, total cholesterol, and triglycerides.(6)
• APIGENIN -  Supports rejuvenation of aging arterial blood vessels. In lab studies, apigenin mitigated age-related vascular inflammation, oxidative stress, and reversed aortic stiffening aging.(7)
• Further apigenin has been shown to be anti-hypertensive and protective against cardiac hypertrophy. (8)

 VASCULAR VX  (ARONIA BERRY | SAFFRON | ARTICHOKE | APIGENIN)

REFERENCES:

(1) Zhao Y, et al. Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.  Sci Rep. 2021 Oct 18

(2) Daskalova E, et al. Black Chokeberry ( Aronia melanocarpa) Functional Beverages Increase HDL-Cholesterol Levels in Aging Rats. Foods. 2021 Jul

(3) Kasprzak-Drozd K, et al. The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases. Int J Mol Sci. 2021 Jun.

(4) Kadoglou N, et al. The cardiovascular-protective properties of saffron and its potential pharmaceutical applications: A critical appraisal of the literature. Phytother Res. 2021 Aug 26.

(5) Xing B, et al. Phytochemistry, pharmacology, and potential clinical applications of saffron: A review  J Ethnopharmacol. 2021 Dec 5.

(6) Santos H, et al. The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacol Res. 2018 Nov

(7) Clayton Z, et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. AM J Physiol Heart Circ Physiol. 2021 Jul 

(8) Gao H, et al. Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus. Cardiovasc Toxicol, 2021 Sept.

YELLOW LONGEVITY® - The Yellows for Longevity Support

Yellow Longevity® is a high quality supplement which contains the most important natural yellows found in nature for health and anti-aging.

Key ingredients:

• CURCUGEN® - from Dolcas-Biotech, is a next generation curcumin complex,  which is an oleoresin-sourced turmeric active. The result is significantly enhanced bioavailability of free curcumin. Tests proved a 39x enhanced bioavailability vs regular 95% Curcumin extract,(1)
• TETRAHYDROCURCUMIN (THC) - Further, Curcugen® is unique in being able to significantly enhance endogenously produced THC bioavailability (by a factor of 31xs more bioavailability vs placebo). THC is stronger antioxidant than curcumin. (2) Additional benefits from THC include cardioprotective against pathological cardiac hypertrophy (enlargement) and fibrosis(3),  and increases lifespan in research animals by increasing FOXO gene factor.(4)
• BERBERINE - Many significant antiaging benefits. Through various pathways, has anti-cancer potential.  Is anti-diabetic and may be beneficial for colitis.(6)  Acts as a protective of retina epithelial cells, and Age-related macular degeneration (AMD)(7). Supports inhibition of atherosclerosis by increasing SIRT1, thereby activating autophagy and apoptosis of peritoneal macrophages. Researchers suggest that this may be a therapeutic for atherosclerosis.(8) 
• SAFFRON - The emerging roles of saffron in degenerative diseases, and anti-aging. Benefits includes, eye protection, depression (anti-neuroinflammation), anti-stress, support for sleep and cardiovascular health.(9) Ameliorates cardiac hypertrophy.(10) 
• APIGENIN - Compelling animal research indicates a potent anti-cancer effect of apigenin. Part of this effect is due to apigenin being a strong antioxidant. Apigenin also effects other pathways involved in cancer development.(11) Slow clearance by the liver enables long lasting effect of apigenin in the body. New research indicates that apigenin may provide  endothelium restoration in aging blood vessels.(12) Aging blood vessels include aorta stiffening and vascular inflammation. Apigenin may prevents foam cell formation (initial step in atherosclerosis), reverse aortic stiffening, and promote normal collagen elastin in arteries as well as reversing arterial inflammation. Researchers indicate that apigenin may provide an effective mechanism in reversing arterial dysfunction.  

 YELLOW LONGEVITY (Curcugen®  | Berberine | Saffron | Apigenin)

REFERENCES:

(1) Dolcas-Biotech Research. 2021

(2) Sanjib K, et al. The enhanced bioavailability of free curcumin and bioactive-metabolite tetrahydrocurcumin from a dispersible, oleoresin-based turmeric formulation. Medicine (Baltimore). 2021 Jul.

(3) Zhang B, et al. Novel PGC-1 α/ATF5 Axis Partly Activates UPR ^mt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy. Oxid Med Cell Longev. 2020 Dec

(4) Shen L, et al. Curcumin and Aging.Biofactors. Jan-Feb 2013 

(5) Samadi P, et al. Berberine: A novel therapeutic strategy for cancer. IUBMB Life. 2020 Oct.

(6) Ashrafizadeh M, et al. Berberine Administration in Treatment of Colitis: A Review. Curr Drug Targets. 2020.

(7) Li, S. et el. Protective Mechanism of Berberine on Human Retinal Pigment Epithelial Cells against Apoptosis Induced by Hydrogen Peroxide via the Stimulation of Autophagy. Oxid Med Cell Longev. 2021 Aug.

(8) Zheng Y, et al Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages. Aging (Albany NY) 2021 Feb

(9) Roshanravan N, et al. The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials. Phytother Res. 2021 Sep

(10) Lin C, et al. IGF-II-induced hypertrophy in H9c2 cardiomyocytes is ameliorated by saffron by regulation of calcineurin/NFAT abd CaMKII signaling. Environ Toxicol. 2021 Sep.

 (11) Kashyap P, et al. Functionality of apigenin as a potent antioxidant with emphasis on bioavailability, metabolism, action mechanism and in vitro and in vivo studies: A review. J Food Biochem. 2021 Sep

(12) Clayton Z, et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 Jul.

Prolongevity: New Evidence of Anti-Aging Effect of Resveratrol

For years, it has been known that resveratrol is one of the most effective anti-aging compounds studied. Beneficial effects on lifespan have been demonstrated across many research organisms, including worms and flies. In 2003, resveratrol was identified as a molecule which could activate SIRT1, mimicking the life extending benefits shown by calorie restriction. Furthermore, resveratrol also activates the anti-aging Nrf2 pathway, and AMPK which enhances NAD+ availability. (1) Cellular NAD+ levels are linked to longevity. 

In a new study, the silkworm was used to further illustrate the life extending effects of resveratrol via significant improvement of antioxidant activity.. Oxidation is a key factor is anti-aging and shortening of the lifespan.(2)

Resveratrol was shown to activate antioxidant function in the silkworm via increased activity of the GST enzyme, key in the antioxidant enzyme system.

RESVERATROL ACTIVATES the GST Antioxidant System via

• SIRT7 (activation) ---> activates FOXO --> activates GST (antioxidant) 

This research further validates the beneficial life extending benefits of resveratrol.

PURPLE LONGEVITY (Resveratrol : Pterostilbene)

REFERENCES:

(1) Li Z, et al. Aging and age‐related diseases: from mechanisms to therapeutic strategies. Biogerontology. 2021 Jan 

(2) Song J, et al.  Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori. J Pharm Anal. 2021 Jun

PURPLE LONGEVITY® - Rich purple Anthocyanins, Activating Longevity Genes Autophagy and Increasing Glutathione

Boosting longevity is a function of many different attributes. Key among these are activating longevity genes (SIRT1 and FOXO) and decreasing levels of oxidative stress. 

ACTIVATING LONGEVITY GENES -

• Resveratrol and Pterostilbene  - Act as antiaging gene activators, including SIRT1 gene activator.(1)
• Resveratrol and Pterostilbene are correlated with longevity.
• Lingonberry (Lowbush Cranberry) contains powerful anthocyanins which activate FOXO longevity genes. (2)
• Lingonberry may have beneficial effects on obesity health issues, including high fat diet cholesterol, glucose and inflammation.(3)

BILBERRY ANTHOCYANINS (Blue Color)

• Significant increases antioxidant capacity and induction of autophagy (4)
• AUTOPHAGY promotes health and longevity.
• AUTOPHAGY - invoked through increased AMPK and reduced mTOR
• AUTOPHAGY further enhanced intestinal epithelial barrier

 GRAPE SEED EXTRACT (GSE) (5-8)

• GSE grape seeds are anti-oxidative, anti-inflammatory and anti-tumor
• Vascular protective. Including blood pressure-lowering effect in hypertensive research animals. 
• Cardio protective properties, especially against cardiac dysfunction after myocardial infarction.
• Offers protection against ischemic stroke, by reducing oxidative stress levels.
• Is a natural aromatase inhibitor, an enzyme involved with converting androgens (testosterone) to estrogen. 

N-ACETYLCYSTEINE (GLUTATHIONE BOOSTER) (9-11)

• Is a precursor to glutathione. Decreases in glutathione are correlated with aging. Levels of cellular glutathione are predictive of longevity. 
• Improved experimental organisms health and longevity. Increased longevity corresponds to Increased levels of antioxidant enzymes (Catalase and Glutathione)
• Supports restoration of intestinal barrier.
• May be effective against cardiovascular events by increasing intracellular glutathione levels. Glutathione reduces  inflammatory IL-1β, which can can promote atherogenesis

 PURPLE LONGEVITY®  

=> (RESVERATROL | PTEROSTILBENE | LINGONBERRY)

REFERENCES:

(1) Li Y, et al. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors. 2018 Jan.

(2) Scerbak C, et al. Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons. Geroscience. 2018 Apr.

(3) Ryyti R, et al. Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity. PLoS One. 2020 May.

(4) Li J, et al. Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats.  J Agric Food Chem. 2019 Jul.

(5) Mas-Capdevila A, et al. Changes in arterial blood pressure caused by long-term administration of grape seed proanthocyanidins in rats with established hypertension. Food Funct. 2020 Oct.

(6) Ruan Y, et al. Grape Seed Proanthocyanidin Extract Ameliorates Cardiac Remodelling After Myocardial Infarction Through PI3K/AKT Pathway in Mice. Front Pharmacol. 2020 Dec. 

(7) Kadri S, et al. Protective effect of grape seed extract and orlistat co-treatment against stroke: Effect on oxidative stress and energy failure. Biomed Pharmacother. 2021  Apr.

(8) Kijima K, et al. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun.

(9) Niraula P, et al. N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression. Biogerontology. 2019 Aug.

(10) McCarty M, et al. Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. Adv Nutr. 2021 Mar.

(11) DiNicolantonio J, et al. Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1β signalling: a potential strategy for preventing cardiovascular events? Open Heart. 2017 Jul.