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Cardiovascular Health -Restoring Arterial Health

Maintaining healthy arteries promotes blood circulation, tissue and organ oxygenation and longer life

VASCULAR VX™ is a next generation vascular support formula, helping to maintain arterial elasticity, and limiting potential for the pathological build-up in the arteries, which is responsible for atherosclerosis.

• ARONIA BERRY (Polysaccharides) - Ameliorates aging and inflammation in research animals, via beneficial support of anti-aging signaling pathways AMPK/SIRT1/NF-κB and Nrf2/HO-1. Significantly, aronia berry increases levels of beneficial bacteria in the intestine which plays an important anti-aging role. (1)
• Increases in HDL cholesterol in aging lab animals.(2)
• Provides comprehensive cardiovascular support. Many studies have shown the efficacy of aronia berry in in vitro and in vivo for cardiovascular health. Indications include beneficial effects on  hypertension, LDL oxidation, lipid peroxidation, total plasma antioxidant capacity and dyslipidemia.(3)
• SAFFRON -  Studies indicate that saffron may have a anti-atherosclerosis role. Important saffron benefits may include atherosclerosis regression and /or stabilization of atherosclerosis in animal models prone to atherosclerosis.(4)  Also clinical studies show positive effects in support of blood circulation.(5) 
• ARTICHOKE - Supports healthy lipid levels. Including decreased LDL, total cholesterol, and triglycerides.(6)
• APIGENIN -  Supports rejuvenation of aging arterial blood vessels. In lab studies, apigenin mitigated age-related vascular inflammation, oxidative stress, and reversed aortic stiffening aging.(7)
• Further apigenin has been shown to be anti-hypertensive and protective against cardiac hypertrophy. (8)

 VASCULAR VX  (ARONIA BERRY | SAFFRON | ARTICHOKE | APIGENIN)

REFERENCES:

(1) Zhao Y, et al. Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.  Sci Rep. 2021 Oct 18

(2) Daskalova E, et al. Black Chokeberry ( Aronia melanocarpa) Functional Beverages Increase HDL-Cholesterol Levels in Aging Rats. Foods. 2021 Jul

(3) Kasprzak-Drozd K, et al. The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases. Int J Mol Sci. 2021 Jun.

(4) Kadoglou N, et al. The cardiovascular-protective properties of saffron and its potential pharmaceutical applications: A critical appraisal of the literature. Phytother Res. 2021 Aug 26.

(5) Xing B, et al. Phytochemistry, pharmacology, and potential clinical applications of saffron: A review  J Ethnopharmacol. 2021 Dec 5.

(6) Santos H, et al. The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacol Res. 2018 Nov

(7) Clayton Z, et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. AM J Physiol Heart Circ Physiol. 2021 Jul 

(8) Gao H, et al. Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus. Cardiovasc Toxicol, 2021 Sept.

YELLOW LONGEVITY® - The Yellows for Longevity Support

Yellow Longevity® is a high quality supplement which contains the most important natural yellows found in nature for health and anti-aging.

Key ingredients:

• CURCUGEN® - from Dolcas-Biotech, is a next generation curcumin complex,  which is an oleoresin-sourced turmeric active. The result is significantly enhanced bioavailability of free curcumin. Tests proved a 39x enhanced bioavailability vs regular 95% Curcumin extract,(1)
• TETRAHYDROCURCUMIN (THC) - Further, Curcugen® is unique in being able to significantly enhance endogenously produced THC bioavailability (by a factor of 31xs more bioavailability vs placebo). THC is stronger antioxidant than curcumin. (2) Additional benefits from THC include cardioprotective against pathological cardiac hypertrophy (enlargement) and fibrosis(3),  and increases lifespan in research animals by increasing FOXO gene factor.(4)
• BERBERINE - Many significant antiaging benefits. Through various pathways, has anti-cancer potential.  Is anti-diabetic and may be beneficial for colitis.(6)  Acts as a protective of retina epithelial cells, and Age-related macular degeneration (AMD)(7). Supports inhibition of atherosclerosis by increasing SIRT1, thereby activating autophagy and apoptosis of peritoneal macrophages. Researchers suggest that this may be a therapeutic for atherosclerosis.(8) 
• SAFFRON - The emerging roles of saffron in degenerative diseases, and anti-aging. Benefits includes, eye protection, depression (anti-neuroinflammation), anti-stress, support for sleep and cardiovascular health.(9) Ameliorates cardiac hypertrophy.(10) 
• APIGENIN - Compelling animal research indicates a potent anti-cancer effect of apigenin. Part of this effect is due to apigenin being a strong antioxidant. Apigenin also effects other pathways involved in cancer development.(11) Slow clearance by the liver enables long lasting effect of apigenin in the body. New research indicates that apigenin may provide  endothelium restoration in aging blood vessels.(12) Aging blood vessels include aorta stiffening and vascular inflammation. Apigenin may prevents foam cell formation (initial step in atherosclerosis), reverse aortic stiffening, and promote normal collagen elastin in arteries as well as reversing arterial inflammation. Researchers indicate that apigenin may provide an effective mechanism in reversing arterial dysfunction.  

 YELLOW LONGEVITY (Curcugen®  | Berberine | Saffron | Apigenin)

REFERENCES:

(1) Dolcas-Biotech Research. 2021

(2) Sanjib K, et al. The enhanced bioavailability of free curcumin and bioactive-metabolite tetrahydrocurcumin from a dispersible, oleoresin-based turmeric formulation. Medicine (Baltimore). 2021 Jul.

(3) Zhang B, et al. Novel PGC-1 α/ATF5 Axis Partly Activates UPR ^mt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy. Oxid Med Cell Longev. 2020 Dec

(4) Shen L, et al. Curcumin and Aging.Biofactors. Jan-Feb 2013 

(5) Samadi P, et al. Berberine: A novel therapeutic strategy for cancer. IUBMB Life. 2020 Oct.

(6) Ashrafizadeh M, et al. Berberine Administration in Treatment of Colitis: A Review. Curr Drug Targets. 2020.

(7) Li, S. et el. Protective Mechanism of Berberine on Human Retinal Pigment Epithelial Cells against Apoptosis Induced by Hydrogen Peroxide via the Stimulation of Autophagy. Oxid Med Cell Longev. 2021 Aug.

(8) Zheng Y, et al Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages. Aging (Albany NY) 2021 Feb

(9) Roshanravan N, et al. The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials. Phytother Res. 2021 Sep

(10) Lin C, et al. IGF-II-induced hypertrophy in H9c2 cardiomyocytes is ameliorated by saffron by regulation of calcineurin/NFAT abd CaMKII signaling. Environ Toxicol. 2021 Sep.

 (11) Kashyap P, et al. Functionality of apigenin as a potent antioxidant with emphasis on bioavailability, metabolism, action mechanism and in vitro and in vivo studies: A review. J Food Biochem. 2021 Sep

(12) Clayton Z, et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 Jul.

Prolongevity: New Evidence of Anti-Aging Effect of Resveratrol

For years, it has been known that resveratrol is one of the most effective anti-aging compounds studied. Beneficial effects on lifespan have been demonstrated across many research organisms, including worms and flies. In 2003, resveratrol was identified as a molecule which could activate SIRT1, mimicking the life extending benefits shown by calorie restriction. Furthermore, resveratrol also activates the anti-aging Nrf2 pathway, and AMPK which enhances NAD+ availability. (1) Cellular NAD+ levels are linked to longevity. 

In a new study, the silkworm was used to further illustrate the life extending effects of resveratrol via significant improvement of antioxidant activity.. Oxidation is a key factor is anti-aging and shortening of the lifespan.(2)

Resveratrol was shown to activate antioxidant function in the silkworm via increased activity of the GST enzyme, key in the antioxidant enzyme system.

RESVERATROL ACTIVATES the GST Antioxidant System via

• SIRT7 (activation) ---> activates FOXO --> activates GST (antioxidant) 

This research further validates the beneficial life extending benefits of resveratrol.

PURPLE LONGEVITY (Resveratrol : Pterostilbene)

REFERENCES:

(1) Li Z, et al. Aging and age‐related diseases: from mechanisms to therapeutic strategies. Biogerontology. 2021 Jan 

(2) Song J, et al.  Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori. J Pharm Anal. 2021 Jun

PURPLE LONGEVITY® - Rich purple Anthocyanins, Activating Longevity Genes Autophagy and Increasing Glutathione

Boosting longevity is a function of many different attributes. Key among these are activating longevity genes (SIRT1 and FOXO) and decreasing levels of oxidative stress. 

ACTIVATING LONGEVITY GENES -

• Resveratrol and Pterostilbene  - Act as antiaging gene activators, including SIRT1 gene activator.(1)
• Resveratrol and Pterostilbene are correlated with longevity.
• Lingonberry (Lowbush Cranberry) contains powerful anthocyanins which activate FOXO longevity genes. (2)
• Lingonberry may have beneficial effects on obesity health issues, including high fat diet cholesterol, glucose and inflammation.(3)

BILBERRY ANTHOCYANINS (Blue Color)

• Significant increases antioxidant capacity and induction of autophagy (4)
• AUTOPHAGY promotes health and longevity.
• AUTOPHAGY - invoked through increased AMPK and reduced mTOR
• AUTOPHAGY further enhanced intestinal epithelial barrier

 GRAPE SEED EXTRACT (GSE) (5-8)

• GSE grape seeds are anti-oxidative, anti-inflammatory and anti-tumor
• Vascular protective. Including blood pressure-lowering effect in hypertensive research animals. 
• Cardio protective properties, especially against cardiac dysfunction after myocardial infarction.
• Offers protection against ischemic stroke, by reducing oxidative stress levels.
• Is a natural aromatase inhibitor, an enzyme involved with converting androgens (testosterone) to estrogen. 

N-ACETYLCYSTEINE (GLUTATHIONE BOOSTER) (9-11)

• Is a precursor to glutathione. Decreases in glutathione are correlated with aging. Levels of cellular glutathione are predictive of longevity. 
• Improved experimental organisms health and longevity. Increased longevity corresponds to Increased levels of antioxidant enzymes (Catalase and Glutathione)
• Supports restoration of intestinal barrier.
• May be effective against cardiovascular events by increasing intracellular glutathione levels. Glutathione reduces  inflammatory IL-1β, which can can promote atherogenesis

 PURPLE LONGEVITY®  

=> (RESVERATROL | PTEROSTILBENE | LINGONBERRY)

REFERENCES:

(1) Li Y, et al. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors. 2018 Jan.

(2) Scerbak C, et al. Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons. Geroscience. 2018 Apr.

(3) Ryyti R, et al. Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity. PLoS One. 2020 May.

(4) Li J, et al. Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats.  J Agric Food Chem. 2019 Jul.

(5) Mas-Capdevila A, et al. Changes in arterial blood pressure caused by long-term administration of grape seed proanthocyanidins in rats with established hypertension. Food Funct. 2020 Oct.

(6) Ruan Y, et al. Grape Seed Proanthocyanidin Extract Ameliorates Cardiac Remodelling After Myocardial Infarction Through PI3K/AKT Pathway in Mice. Front Pharmacol. 2020 Dec. 

(7) Kadri S, et al. Protective effect of grape seed extract and orlistat co-treatment against stroke: Effect on oxidative stress and energy failure. Biomed Pharmacother. 2021  Apr.

(8) Kijima K, et al. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun.

(9) Niraula P, et al. N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression. Biogerontology. 2019 Aug.

(10) McCarty M, et al. Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. Adv Nutr. 2021 Mar.

(11) DiNicolantonio J, et al. Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1β signalling: a potential strategy for preventing cardiovascular events? Open Heart. 2017 Jul.

Lycium Barbarum - for Vision (Retina) | Longevity | Intestinal Health and Slows Aging!

Lycium Barbarum (LB), also known as wolfberry, has been shown to provide powerful anti-aging effects. Significantly, long term feeding of LB in lab animals have shown increased longevity, eye (retina) support, including age-related macular degeneration (AMD), support liver health and boost of intestinal health and immunity.(1)

  INCREASING MEAN LIFESPAN

• Studies involving D. melanogaster (fruit fly), shown LB increases serum and organ levels of superoxide dismutase (SOD), reduced glutathione and catalase (CAT) antioxidant activity. SOD and CAT have been shown in research models to promote longevity. (2)
• Positively promotes anti-aging pathways (MAPK, TOR, S6K) and increases expression of longevity genes (2)

PRESERVING RETINA FUNCTION

• Retinal diseases have underlying high levels of oxidative stress. Photoreceptors and RPE (Retinal Pigment Endothelium) have very high metabolic activity and additional stress comes from photooxidative damage (due to light). Oxidative stress in the retina leads to increased amounts of lipofuscin - which is formed from oxidative by products and can trigger retinal damage and apoptosis. 
• LB has shown potential support for retinal diseases. While most studies have been in animal models, long term studies and human studies still need to be done. Retinal diseases which may benefit from LB include (3)
• Age-Related Macular Degeneration (AMD) - in early AMD LB has slowed progression and inhibited soft drusen formation.
• Diabetic Retinopathy (DR) - In animal studies, LB restored retinal thickness, reversed hyperglycemic oxidative stress, promoted reductions in retinal vascular changes seen in diabetic retinopathy. Reversed increased VEGF vascular growth factor - which increases vascularization in DR. Also enhanced protection of blood-retinal-brain barrier (which is disrupted by diabetes), causing macular edema. 
• Retinitis Pigmentosa - an inherited genetic disease of the retina. LB may improve visual processing by increasing antioxidant protection  of photoreceptors.
• LB significant increases antioxidation levels, while inhibiting lipid peroxidation (fatty acids are prevalent in photoreceptor membranes).
• LB is the richest source of natural Zeaxanthin. Contains very high bioavailable Zeaxanthin (demonstrated in animals and humans)

PROMOTES INTESTINE HEALTH / IMMUNE RESPONSE

• Strengthens the intestinal barrier, which is critical for maintaining a healthy functioning intestine.LB Promotes increased production of short chain fatty acids (which is anti-inflammatory)
• Promotes intestinal immunity (1)  Support general immune response through changes in gut microbiota  and increases in short chain fatty acids.(5)

PROTECTS LIVER 

• Attenuates liver cell damage from environmental contaminants (plastics), in addition to alcohol toxicity by increasing levels of Nrf2, a master regulator of cellular antioxidants in the cell. As a result,  Nrf2 triggers significant increases in cellular antioxidant activity and inhibiting apoptosis of the liver cells. Alcohol induced damage to the liver is a result of increased oxidative stress and destruction of the cells.(1,6,7)

VISION VITALITY  (Lycium Bararum)

REFERENCES:

(1) Ding Y, et al. Effects of long-term consumption of polysaccharides from the fruit of Lycium barbarum on host's health.  Food Res Int. 2021 Jan.

(2) Tang R, et al. Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster.  Food Funct. 2019 Jul.

(3) Neelam K, et al. Fructus lycii: A Natural Dietary Supplement for Amelioration of Retinal Diseases. Nutrients. 2021 Jan.

(4) Ding Y, et al. Modulating effects of polysaccharides from the fruits of Lycium barbarum on the immune response and gut microbiota in cyclophosphamide-treated mice.

(5) Ding Y, et al. Modulating effects of polysaccharides from the fruits of Lycium barbarum on the immune response and gut microbiota in cyclophosphamide-treated mice. Food Funct. 2019 Jun.

(6) Liu R, et al. Protective effect of Lycium barbarum polysaccharide on di-(2-ethylhexyl) phthalate-induced toxicity in rat liver. Environ Sci Pollut Res Intl. 2021. Jan.

(7) Wang H, et al. Hepatoprotective effect of crude polysaccharide isolated from Lycium barbarum L. against alcohol-induced oxidative damage involves Nrf2 signaling. Food Sci Nutr. 2020 Oct..

CURCUMIN PXC® - The Proteostasis Curcumin® and Fisetin for Longevity

PROTEOSTASIS. Defines the ability of the body to maintain the fidelity of  biogenesis of protein (non-defective proteins), folding. movement, and removal of old protein aggregates. Especially significant is the removal of old damaged protein aggregates, which are detrimental to the functioning of the cell. Clearing old cellular debris, through a process called autophagy, greatly enhances the youthful functioning of the cell. 

CURCUMIN ENHANCES AUTOPHAGY. Lifespan and autophagy are strongly
 associated with one another.  Calorie restriction, resveratrol and curcumin are known to improve autophagy and increase lifespan. In fact, all life extension mechanisms depend upon the importance of autophagy for clearing cellular damage.(1,2)

Aging affects molecular pathways that influence health and longevity. As a result, there is a reduction of cellular debris clearance (autophagy), decreased  the pool of stem cells, increase in inflammation and cellular senescence. 

CURCUMIN has been shown to by positively regulate longevity by through important molecular pathways, including IIS, mTOR and FOXO. Curcumin is a powerful activator of the body's antioxidant defense system, as an Nrf2 activator. As an antioxidant, curcumin stabilizes and protects telomeres. Inflammation is also a powerful promoter of aging. Curcumin inhibits the powerful inflammation transcription factor NF-κB and is associated with reduced levels of inflammation.(3)  PROTEOSTASIS is impacted by all these aging pathways.(4) Therefore, curcumin supports longevity via aging signaling and proteostasis (autophagy).

• NEURODEGENERATION AND AUTOPHAGY.

Misfolded proteins in the brain are associated with poorly functioning autophagy. Autophagy removes aggregate protein accumulations which is responsible for neurodegeneration. Curcumin, research indicates, may help restore autophagy in the brain, to clear these misfolded proteins. (5) Oleuropein, a component of Olive Oil, in addition to curcumin, is implicated in mitophagy in the brain, removing old and dysfunction mitochondria. (6)

• SIRT1 (SIRTUINS) ENHANCES PROTEOSTASIS

SIRT1 is an enzyme which regulates cellular processes relative to longevity. SIRT1 INCREASES PROTEOSTASIS ,which is an important component of the longevity effect. Natural activators of SIRT1 include Curcumin, Fisetin, Quercetin and Resveratrol.(15)

• ATRIAL FIBRILLATION: PROTEOSTASIS AUTOPHAGY & INFLAMMATION

Cardiac remodeling through failure of autophagy, proteostasis and inflammation are believed to be a root cause of atrial fibrillation. Cardiomyocytes are replaced by non-functional proteins..(12. 13)  

• PROTEOSTASIS DECLINE SIGNIFICANTLY IMPACTS AGING. (7)

With age, cells become replicative scenescent - losing ability to produce new cells. Furthermore, scenescent cells are old cells. Old cells have been shown to lose proteostasis, which further limit the abilty of the cell to respond to external threats and maintain function. Curcumin and pterostilbene(11) helps inhibit cellular scenescence. Fisetin and quercetin are considered senolytics, which are capable of removing scenescent cells. (10)  Importantly, recent research also indicates that curcumin also removes scenescent cells.(14)

CURCUMIN PXC® - Incorporates highly bioavailable curcumin  Furthermore, Curcumin PXC also includes powerful supplemental ingredients in support of proteostasis.

• AUTOPHAGIX™ Complex - Rutin, Lonicera japonica (8), Oleuropein, Quercetin. 
• ROSEMARY PROTEOSTASIS™ COMPLEX (9)
• FISETIN (10)
• TRANS-PTEROSTILBENE

CURCUMIN PXC® - THE PROTEOSTASIS CURCUMIN® 

REFERENCES:

Rosmarinic Acid - Suppression amyloid beta / Tau, and/or α-synuclein

The formation of insoluble fibers in the brain, including amyloid beta, Tau and α-synuclein are associated with dementia (especially correlated with aging). As such, targeted suppression and removal of these fibrils may be a strategic method of improving disease progression.

Results of studies demonstrated that Spearmint extract and Rosmarnic Acid (a component of Spearmint) can suppress the formation of amyloid fibrils. Furthermore, Rosmarinic Acid may breakdown already formed amyloid beta, Tau and α-synuclein fibrils.(1) Myricetin, another phenolic compound, also exhibits suppression of α-synuclein fibrils.(2)

In the brain, dementia Lewy Bodies involve primarily α-synuclein fibrils, while Alzheimer's Disease involve primarily amyloid beta fibrils.

HYPER LONGEVITY®  (contains ROSMARINIC ACID / MYRICETIN)

CURCUMIN PXC® (contains ROSMARINIC ACID)

NEUROTREX® (contains ROSMARINIC ACID / MYRICETIN)

REFERENCES:

1. Ojawa K,  et al. Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia. Nutrients. 2020 Nov 13.

2. Takahashi R, et al. Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity. J Neurochem. 2015 Sep.