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Higher Brain Glucose | Prediabetes Diabetes - Connection to Dementia - Alzheimer's Disease

December 01, 2017

Scientific evidence indicates that higher levels of blood glucose in the brain, due to the inability of the brain to process the glucose (impaired fasting glucose metabolism) is strongly linked to cognitive decline including brain shrinkage and dementia including Alzheimer's Disease (AD). Neurons in the brain must have a continuous supply of glucose, which is utilized as their primary energy source. Transport of glucose into the neuron is through the  glucose transport proteins GLUT1 and GLUT3 which are not dependent on insulin. Since the brain is so dependent on GLUT1 and GLUT3 to sustain energy for the function of the neurons, any loss of GLUT functioning results in the death of neurons. Furthermore. the higher levels of uncontrolled glucose causes...

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Hypothalmus - Role in Aging and longevity

October 18, 2017

The hypothalamus is a small structure in the brain which is involved in important physiological functions including homeostasis and systemic energy balance, which support health and longevity. Recent research indicates that the neural stem cells found within hyopathalamus may be key to slowing the aging process. However, this not through neurogenesis, but by the secretion of exosomes and microRNA content. (1) Exosomes are vesicles released by the stem cells into the cerebrospinal fluid. Exosomes are an important mechanism for cell-to-cell communications. communication. The content of exsomes include microRNAs, which modifies the expression of genes in the recipient cell.   Inflammation and the Hypothalamus Longevity of Hypothalamus Neural Stem Cells (Hnsc). With aging there is a significant increase in inflammation, which negatively...

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Yellows - Activating FOXO Longevity Factors and Longevity Pathways

August 11, 2017

It is known that the activation of FOXO transcription factors promote extreme longevity, which has been demonstrated in research animals as well as in animals such as the multi-cell animal hydra. In  human longevity, those with gene variants which activate higher levels of FOXO are also the longest lived with least amounts of illness and disease. Despite years of research declaring that antioxidants, such as vitamins C and E, promoted longevity, none have been shown to activate the longevity factors FOXO or Nrf2. Rather, potent longevity factor activation has been shown by many plant based flavonoids. (1) Flavonoids are yellow in nature, and the word is derived from the latin flavus, which means yellow.   FLAVONOIDS - APGEININ & LUTEOLIN...

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Vision Longevity - Activating Nrf2 in the Retina by Lutein Zeaxanthin and Meso zeaxanthin

July 02, 2017

It has been well studied that the carotenoids lutein and zeaxanthin play an important role in preserving eye function by directly acting as antioxidants. However, new research indicates that these powerhouses go one important step further. This is through the activation the Nfr2 antioxidant defense network. Nrf2 is a latent protein in the cell, that when activated, becomes a powerful transcription factor that turn on the Antioxidant Response Element (ARE). ARE is the master antioxidant switch in the cell and provides overwhelming antioxidant response, including increased levels of the potent cellular protector glutathione. LUTEIN ZEAXANTHIN and MESO ZEAXANTHIN act as both direct antioxidants and as Nrf2 activators. Significantly, this makes their protection capacity for the retina significantly greater than only...

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