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Vision Longevity - Activating Nrf2 in the Retina by Lutein Zeaxanthin and Meso zeaxanthin

July 02, 2017

It has been well studied that the carotenoids lutein and zeaxanthin play an important role in preserving eye function by directly acting as antioxidants. However, new research indicates that these powerhouses go one important step further. This is through the activation the Nfr2 antioxidant defense network. Nrf2 is a latent protein in the cell, that when activated, becomes a powerful transcription factor that turn on the Antioxidant Response Element (ARE). ARE is the master antioxidant switch in the cell and provides overwhelming antioxidant response, including increased levels of the potent cellular protector glutathione. LUTEIN ZEAXANTHIN and MESO ZEAXANTHIN act as both direct antioxidants and as Nrf2 activators. Significantly, this makes their protection capacity for the retina significantly greater than only...

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Cardiac Aging - Heart Failure and Limits of Longevity

May 28, 2017

While we live in an age where people are living longer, an important limiting factor on longevity is the ability of the heart to maintain function.  Known causes of death for the oldest people on record (over 110 years old) were recorded as heart failure. Heart failure is due to the gradual loss of cardiomyocytes (heart muscle cells) and the increase in scarring of the heart muscle. The process may take place due to low grade inflammation of the muscle, which progresses with age, or injury (such as a heart attack) which may cause a more sudden loss of heart function. Inflammation in  the cardiovascular system is common with the aging process, being the result of hypertension, high blood glucose,...

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Prevention of Lipid Oxidative Damage and Anti-Inflammation - Lutein Zeaxanthin Mesozeaxanthin

April 27, 2017

Protective macular pigments consist of lutein, zeaxanthin and meso zeaxanthin which act as powerful lipid antioxidants as well as functioning as an anti-inflammatory in the retina. In both the retina and the brain, these pigments are readily absorbed into the cellular membranes and orient themselves perpendicular in the membrane which acts to stabilize the cellular membrane.(1) The cellular membrane is made from unsaturated fats, which are very susceptible to free radical induced oxidative damage by high energy short wave light (such as blue light). As a potent lipid antioxidants, lutein, zeaxanthin and meso zeaxanthin signifcantly boost protection of the cellular membrane, and thereby protecting cells of the retina cells and neurons in the brain.(2) All three xanthophylls function as potent...

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Sulforaphane and Prostate Cancer - the role of Non-Coding RNA

April 09, 2017

New biomarkers have been identified that may help in the early diagnosis and treatment of prostate and urological cancers.  Long non-coding RNA (Ribonucleic Acid), a form of RNA not involved in cellular protein encoding, are altered in these cancers.(1,2) Expression of long non-coding RNA is believed to play a significant role in the initiation and progression of prostate cancer. Sulforaphane has been found to inhibit the expression of  non-coding RNA associated with prostate cancer. Researchers conclude that sulforaphane may prevent and suppress prostate cancer by the inhibition of key non-coding forms of RNA. (3)    XGEVITY (contains Glucoraphanin - Sulforaphane precursor) AIR VITALITY (contains Glucoraphanin - Sulforaphane precursor)     REFERENCES: (1)  Martens-Uzunova ES, et al. Long noncoding RNA in...

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