WELCOME TO GERES DENGLE!

Thank you for visiting our site. We offer select nutrition supplement products from the finest sources world wide. Our finished products provide what you would expect from a quality supplement, including exceptional value. We hope you enjoy your visit to our site!

FREE SHIPPING on orders of $75 or more (for standard shipping in USA).

News

Oxidative Stress and Inflammation - Pathogenesis in Degeneration of the Retina

October 11, 2019

Neurodegenerative diseases of the retina are mostly attributable to oxidative stress and inflammation.(1)  Diseases of the retina target the retinal epithelial cells, and photoreceptors. Photoreceptors are the processing centers in the retina, and are the primary area of vision. The retina has the highest metabolic rate of any tissue in the body. Furthermore, the retina must endure oxidative stress from chronic exposure to light, which will damage the retina. In addition, retina degeneration is associated with inflammation. The result is that with age, the retina becomes damaged, and blindness is the end effect in older people.   AGE RELATED MACULAR DEGENERATION. Degeneration of retinal cells (photoreceptor and retinal pigment epitheilium (RPE) cells) by oxidative stress and inflammation is responsible for...

Continue Reading →

Curcumin & Fisetin - Amyloid Autophagy & Senolytics. Implications for Longevity and Brain Health

September 27, 2019

Protein Homeostasis is a significant determining factor in the longevity of multi-cellular animals.(1) Quality control mechanisms in place to support protein homeostasis include autophagy - the essential degradation of toxic proteins. As an organism ages, protein homeostasis is gradually lost.(2) Autophagy, by lysosomes, plays an active role in protein homeostasis, by eliminating toxic and damaged proteins such as amyloid. Nrf2 activation increases autophagy activity. Reduced levels of autophagy are tied to Alzheimers Disease. Misfolded amyloid beta and tau proteins are involved in the development of Alzheimers Disease.(11)  Autophagy is not only critical in the deposition of toxic proteins, but is functionally important in the degradation and recycling of defective cellular components. Research now indicates that autophagy is central for maximum...

Continue Reading →

Fisetin - Potent for Anti-Aging Senolytics and Homeostasis

September 20, 2019

In the field of anti-aging, the flavonoid fisetin is emerging as a potent longevity compound. Fisetin affects the aging process in experimental animals through multiple pathways, including senolytics (removing senescent cells)m SIRT1 activation, calorie restriction mimic and homeostasis. SENOLYTICS Senolytics- the rejuvenation of the cellular environment, by eliminating senescent cells. Aging is characterized by the accumulation of senescent cells. These are cells which are irreversibly unable to grow and function and are resistant to normal cellular clearance. Senescent cells not only interfere with normal tissue functioning, but may also be toxic to neighboring cells. Fisetin, has been shown to be a potent senolytic, with the ability to eliminate senescent cells. (1) Scenescent Cells Accelerate Aging. Scenescent cells promote inflammation, stem...

Continue Reading →

Carnosic Acid - Protects Retina and Supports Healthy Cartilage

May 16, 2019

Carnosic acid, an extract from the herb Rosemary, is a powerful activator of cellular endogenous antioxidants, through involvement in increasing Nrf2 transcription.  Since carnosic acid crosses the blood-brain barrier, there is significant provisioning of protection of the brain and neural tissue.(1) In addition, the retina is primarily neural tissue, which benefits greatly from carnosic acid.           RETINA - MITIGATING AGING EYE DETERIORATION Reduces Light Induced Damage - Continued light exposure created free  radicals in the retina, which are destructive to the photoreceptors. (1,2) Age-Related Macular degeneration (AMD) - Photoreceptors are also loss in AMD. Studies involving lab animals suggest that the addition of carnosic acid (rosemary extract) to other vision supplements, i.e. AREDS, may maximize effectiveness in reducing retinal damage. (3)...

Continue Reading →