Cardiovascular disease is a significant causative factor in mortality. Saffron has important anti-aging benefits including improvement of cardiovascular health. The bioactive constituents of saffron (Crocin and Crocetin) play major roles in cardiovascular fitness.
Significantly, saffron may therapeutically provide cardiovascular benefits in the following manner: (1)
(1) Roshanravan N, et al. The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials. Phytother Res. 2022 Jan
Atherosclerosis is a chronic degenerative disease condition which slowly blocks arteries, accelerate aging and is a contributing factor in most age-related deaths.The key event in the initiation and progression of atherosclerosis is injury and inflammation to the arterial lining (endothelial cells).
(1) Tang T, et al. Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2-mediated AMPK/STAT3 pathway in an atherosclerosis rat model. Exp Ther Med. 2020 Jan
(2) Rath S, et al. Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia. Front Microbiol. 2020 Jan
(3) Singh G, et al. High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction. Int J Mol Sci 2019 Jul
(4) Koh YC, et al. Prevention of Vascular Inflammation by Pterostilbene via Trimethylamine-N-Oxide Reduction and Mechanism of Microbiota Regulation. Mol Nutr Food Res. 2019 Oct.
(5) Zhang L, et al. Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo. Apoptosis. 2012 Jan
(6) Kang LL, et al. Pterostilbene Attenuates Fructose-Induced Myocardial Fibrosis by Inhibiting ROS-Driven Pitx2c/miR-15b Pathway. Oxid Med Cell Longev. 2019 Dec
The unique flavonoids in citrus bergamia (Bergamonte®) have been previously shown to have potent cardioprotective properties including effective cholesterol support. Further research indicates that citrus bergamia flavonoids have additional beneficial properties which affect disease progression and longevity.(1)
Bergamonte® is a registered trademark of HP Ingredients.
(1) HP Ingredients October 2016.
(2) Salminen A, et al. Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. Ageing Res Rev. 2016 Jul;
Arteries degenerate with age, via a process known as vascular remodeling, leading to atherosclerosis, stroke and other cardiovascular diseases.. Therefore, preserving youthful arteries is a very important factor in longevity. Two important supplements which have been shown to suppress degenerative changes to the arteries are vinpocetine and citrus bergamot polyphenols.
VASCULAR AGING - Involves changes to the vascular endothelium and smooth muscle which promotes increased hypertension and stiffness of the arteries. The results is an aged vascular system which is characterized by inflammation and atherosclerosis. As such, the arteries lose their ability to expand and contract, and becomes stiff, thickened and inflamed. When the vascular system ages it becomes more susceptible to hypertension, ischemic stroke and coronary heart blockage (heart attack). Furthermore, vascular aging in the brain may lead to cognitive disorders due to diminished blood flow.
Key areas of Vascular Aging:
Promotes youthful arteries via two mechanisms. Vinpocetine reduces the release of inflammatory cytokines from endothelial cells and vascular smooth muscle by targeting oxidative stress and inflammation of the arteries. NF-kB. Also, vinpocetine is a powerful inhibitor of PDE1.
CITRUS BERGAMOT (Bergamonte®) - The polyphenols in Citrus Bergamot uniquely provide artery anti-aging benefits. Citrus Bergamot provides protection directly to the vascular endothelium, in addition to optimizing cholesterol and triglycerides and inhibiting non alcoholic liver disease.
(1) Chan S, et al. PDE1 isozymes, key regulators of pathological vascular remodeling. Curr Opin Pharmacol. 2011 Dec
(2) Bautista N, et al. Phosphodiesterase 1 regulation is a key mechanism in vascular aging. Clin Sci (Lond) 2015 Dec
(3) Zhuang J, et al. Inhibitory effects of vinpocetine on the progression of atherosclerosis are mediated by Akt/NF-κB dependent mechanisms in apoE-/- mice. PLoS One. 2013 Dec.
(4) Yan, C. Cyclic nucleotide phosphodiesterase 1 and vascular aging. Clin Sci (Lond). 2015 Dec.
(5) Chen M, et al. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther. 2002 Jul
(6) HP Ingredients. Support against NAFLD in those with Metabolic Syndrome. 2016 Apr.
(7) HP Ingredients. 2016.
POWERFUL YELLOWS AND AGING. Apigenin and Luteolin. Many changes occur during the aging process, with the most profound being inflammation. Inflammation contradicts good health and becomes increasingly unregulated with age. Since inflammation is key in accelerating aging, it is important to modulate these effects, especially in the brain.
The gradual destruction of neurons by chronic inflammation (neuroinflammation) leads to brain deterioration and pathologies. In the arteries, inflammation facilitates the initiation and rapid onset of arteriosclerosis. It also is responsible for creating immune system dysfunction and autoimmune disease. Another affliction of the aging process is cancer, which is tightly associated with inflammation and cellular dysregulation. Apigenin and luteolin have both shown promise in supporting health aging including ensuring a healthy inflammatory response.
Cardiovascular Artery Inflammation
Brain Degeneration / Neuroinflammation
1. Escande C, et al. Flavonoid Apigenin Is an Inhibitor of the NAD(+)ase CD38. Diabetes. 2013 Apr.
2. Braidy N, et al. Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology. 2014 Apr;
3. Blackwell TK, et al. SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med. 2015 Aug.
4. Paredes-Gonzalez X, et al. Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin. Biopharm Drug Dispos. 2015 Apr
5. Wang Q, et al. Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis. Int Immunopharmacol. 2015 Jul;
6. Zeng P, et al. Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. Oxid Med Cell Longev. 2015
7. Yuan Y, et al. Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia. BMC Neurosci. 2014 Nov
8. Wang S, et al. Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation. Neuroscience. 2011 Jun
9. Theoharides TC, et al. Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin. Front Neurosci. 2015 Jul
10. Huang F, et al. The inhibitory effect of luteolin on inflammation in LPS-induced microglia. Zhong Yao Cai. 2011 Nov
11. Taupin P. Neurogenic drugs and compounds. Recent Pat CNS Drug Discov. 2010 Nov
12. Li R, et al. The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice. Neurosci Lett. 2015 May
13. Liu R, et al. The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice. J Alzheimers Dis. 2011
14. Kritas SK, et al. Luteolin inhibits mast cell-mediated allergic inflammation. J Biol Regul Homeost Agents. 2013 Oct-Dec
17. Banerjee K, et al. Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. Redox Biol. 2015 Apr
18. Tang AQ, et al. Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells. Mol Med Rep. 2015 Mar.
19. Liu J, et al. Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α. Mol Med Rep. 2015 Jan
21. Ma L, et al. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Mol Med Rep. 2015 Sep
22. Davies AH, et al. Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells. Oncotarget. 2015 Aug
23. Bumke-Vogt C, et al. The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells. PLoS One. 2014 Aug
24 Zhang Y, et al. Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway. Eur J Histochem. 2015 Apr
25. Chen X, et al. Scutellarin attenuates hypertension-induced expression of brain Toll-like receptor 4/nuclear factor kappa B. Mediators Inflamm. 2013