HYPER LONGEVITY™ Promoting Healthy and Beautiful Skin
TETRAHYDROCURCUMIN
Increases Lifespan. The major metabolite of curcumin and is a potent anti-aging compound. In research studies tetrahydrocurucmin has been shown to significantly extend lifespan by increasing activation of potent longevity FOXO transcription factors. Further, tetrahydrocurcumin has a direct protective effect on the antioxidant status of skin cells, protecting them from oxidation (acting as a powerful antioxidant of lipid oxidation of the cellular membrane), which prevents cellular senescence.
• Lifespan Extension
& Skin Anti-Aging
EXTENDS LIFESPAN IN RESEARCH ANIMALS
Tetrahydrocurcumin invokes powerful anti-aging FOXO transcription factors in cells, which targets gene expression for anti-aging. Research studies have shown signifcant increases in the lifespan of research animals.(1,8)
PREVENTS PREMATURE SENESCENSE OF SKIN CELLS
Skin aging is associated with an increased level of lipid peroxidation (7), which damages the skin cell, causing premature cellular senescence and an inability to maintain healthy skin. Tetrahydrocurcumin offers significant protection against lipid membrane oxidation of the skin cells and is markedly stronger than regular curcumin.(5,6)
GLYCATION & SKIN DAMAGE REDUCTION
Significantly reduced collagen damage cross-linking associated with increased blood sugar in diabetic rats. Damaged collagen in the skin due to glycation is an age accelerator in the skin.(2) Tetrahydrocurcumin was shown to be a more effective agent than curcumin in reducing glycation. Concomitant with reductions in glycation are a reduction in blood glucose and increase in the number of insulin binding sites by tetrahydrocurcumin.(3)
LIVER PROTECTANT | SUPPORTS DETOXIFICATION.
The liver is the major organ of the body responsible for detoxification of harmful substances in the body. When the liver is not functioning properly, toxins not neutralized can create problems throughout the body, including the skin. Tetrahydrocurcumin is a potent liver protector, supporting healthy functioning of the liver. (4)
NEXT: Skin Anti-Aging <Collagen and Hyaluronic Acid>
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REFERENCES:
(1) Xiang L, Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor. Aging (Albany NY). 2011 Nov;3(11):1098-109.
(2) Pari L, et al. Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes. Fundam Clin Pharmacol. 2007 Dec;21(6):665-71.
(3) Murugan P, et al. Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. J Biosci. 2008 Mar;33(1):63-72.
(4) Osawa T. Nephroprotective and hepatoprotective effects of curcuminoids. Adv Exp Med Biol. 2007;595:407-23.
(5) Khopde SM, et al. Inhibition of radiation-induced lipid peroxidation by tetrahydrocurcumin: possible mechanisms by pulse radiolysis. Biosci Biotechnol Biochem. 2000 Mar;64(3):503-9. .
(6) Somparn P, et al. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull. 2007 Jan;30(1):74-8.
(7) Peres PS, et al. Photoaging and chronological aging profile: Understanding oxidation of the skin. J Photochem Photobiol B. 2011 May 3;103(2):93-7.
(8) Shen LR, et al. Curcumin and aging. Biofactors. 2013 Jan 17. doi: 10.1002/biof.1086.
