Hyper Longevity® 60 VCapsules


 

 

Pro-Longevity Pathways Supporting Extreme Aging. FOXO Support. Discount Qty Pricing!

LABEL INFORMATION

QTY Pricing:

QTY 1:   $29.95 each

QTY 3:   $28.95 each

 

HYPER LONGEVITY® is an advanced anti-aging formula, which supports molecular anti-aging gene activation as well as higher level anti-aging functioning.

 

ANTI-AGING PATHWAYS

  •  Rosemary Extracts (Ursolic Acid / Rosmarinic Acid)
    • Ursolic Acid:
    • Longevity - Involved in Dietary Restriction Longevity via Sir 2.1 and JNK pathways.(1,2)
    • JNK-1 is actively involved with longevity by trans-locating the FOXO/DAF16 protein into the nucleus whereby activating anti-aging effects.(3)
    • Activation of the DAF-16 (FOXO equivalent in nematods) is ESSENTIAL for longevity in c. elegans.(4)
    • Protein Homeostasis, Reduces toxic Protein Aggregation (1) Effective protein homeostasis is a major key in longevity, and is attributable to the extremely long life of naked mole rats.
    • Intestine anti-inflammation
    • Rosmarinic Acid:
    • Longevity - Studies indicate that rosmarinic acid extended longevity in lab animals (c. elegans).
    • Arterial and Skin Elasticity. Rosmarinic acid may be beneficial is reducing glycation related damage in the arteries and skin, thereby improving arterial and skin elasticity in healthy adults.(3)
    • intestine anti-inflammation
  • Fucoidan (Brown Seaweed Extract)
    • Fucoidan:
    • Sirt6 Activator (anti-aging sirtuin)
    • Sirt6 Protection of intestine
    • Stem Cell Mobilizer
    • In animal lab studies, shown to improve atherosclerotic lesions (8)
  • Jujube
    • FOXO Activator
  • Myricetin -
    Significantly extends lifespan in research animal c. elegans by activating longevity factor DAF-16 (homologous to FOXO in mammals),(9) In addition, myricetin acts as a mitochondria activating agent. Increases exercise physical endurance by promoting mitochondria density via activation of SIRT1(10).
  • Baical Skullcap (Baicalin)  - Anti-fibrotic activity.
  • Ashwagandha
    • Stem Cell Longevity - Supports active stem cells, via increases in proliferation and by delaying stem cell senescence.(5)
    • Activates & Maintains Anti-Aging Pathways. Serum levels of two important anti-aging decrease significantly with age. These include FOXO3A and SIRT3. In recent studies, ashwagandha was shown to increase and maintain serum levels of FOXO3A and SIRT3.(6)
    • Ashwagandha also modulates insulin signaling pathways, which is a factor in FOXO activation.(7)

 

REFERENCES:

1. Negi H, et al. 3β-Hydroxy-urs-12-en-28-oic (Ursolic) Acid Modulates Dietary Restriction Mediated Longevity and Ameliorates Toxic Protein Aggregation in C. elegans. J Gerontol A Biol Sci Med Sci. 2017 Nov

2. Negi H, et al. 3β-Hydroxy-urs-12-en-28-oic (Ursolic) acid prolongs lifespan in C. elegans by modulating JNK-1. Biochem Biophys Res Commun. 2016 Nov

3. Yui S, et al. Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults. J Nutr Sci Vitaminol (Tokyo) 2017

3. Oh SW, et al. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci USA. 2005 Mar 

4. Zhao L, et al. The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68. Scientific Reports 7, Article number: 7408. Aug 2017.

5. Sanap A, et al. Herbal Pre-Conditioning induces proliferation and delays senescence in Wharton's Jelly Mesenchymal Stem Cells. Biomed Pharmacother, 2017 Sep

6. Prahan R, et al. Longevity and healthy ageing genes FOXO3A and SIRT3: Serum protein marker and new road map to burst oxidative stress by Withania somnifera.  Exp. Gerontol. 2017 Sep

7. Akhoon BA, et al. Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans. Exp Gerontol. 2016 Jun

8. Patil NP, et al. Algal Polysaccharides as Therapeutic Agents for Atherosclerosis. Front. Cardiovasc Med. 2018 Oct

9. Butcher C, et al. Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF-16. Int J Mol Sci. 2013 Jun.

10. Jung HY, et al. Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α. Sci Rep. 2017.

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