Joints and Cartilage

Healthy Cartilage – Protecting Joints | Preventing Cartilage Aging and Degradation

 

Osteoarthritis: Cartilage degeneration related to aging and injury, with the end result being the destruction of the protective cartilage on the joint bones (known as articular cartilage). Osteoarthritis, also known as degenerative arthritis, is a painful and increasingly debilitating disease. Eventually, the cartilage is on the end on the bones is completely loss, a result of damage and inflammatory degeneration, with bone rubbing against bone. Swelling, inflammation and pain are common. The joint pain can render a person unable to perform basic tasks involving movement, including simple walking. Under extreme conditions, treatment may involve joint replacement surgery.
Natural Support for Osteoarthritis

 

Rheumatoid arthritis: Is a chronic systemic inflammatory autoimmune disease, which targets synovial joints. Synovial joints are the most common and movable joints in the body. The pathological path of rheumatoid arthritis leads to the destruction of articular cartilage and rigidity of the joint and may affect other areas of the body. Unlike osteoarthritis, which occurs primarily at more advanced ages, rheumatoid arthritis can strike at almost any age.
Natural Support for Rheumatoid Arthritis

 

Gout - a form of Inflammatory Arthritis: Caused by high levels of uric acid (hyperurecemia) and is characterized by the occurence of acute inflammatory arthritis, which is a red, tender and painful swelling of the joint. Dietary yellow flavonoids, especially luteolin and apigenin, appear to display activity of lowering uric acid levels and having a positive effect on gout symptoms. (19, 20)

 

 

REFERENCES:

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11. Shin GC, et al. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chem Biol Interact. 2009 Nov 10;182(1):29-36.
12. Pap, T, et al. Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2000;2(5):361-367
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15. Shin GC, et al. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chem Biol Interact. 2009 Nov 10;182(1):29-36
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17. Park C, et al. Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. Int J Mol Med. 2007 Sep;20(3):365-72.
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19. Mo SF, et al. Hypouricemic action of selected flavonoids in mice: structure-activity relationships. Biol Pharm Bull. 2007 Aug;30(8):1551-6.
20. Flemmig J, et al. Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. Phytomedicine. 2011 May 15;18(7):561-6.