Healthy Cartilage – Protecting Joints | Preventing Cartilage Aging and Degradation
Osteoarthritis: Cartilage degeneration related to aging and injury, with the end result being the destruction of the protective cartilage on the joint bones (known as articular cartilage). Osteoarthritis, also known as degenerative arthritis, is a painful and increasingly debilitating disease. Eventually, the cartilage is on the end on the bones is completely loss, a result of damage and inflammatory degeneration, with bone rubbing against bone. Swelling, inflammation and pain are common. The joint pain can render a person unable to perform basic tasks involving movement, including simple walking. Under extreme conditions, treatment may involve joint replacement surgery.
Natural Support for Osteoarthritis
Rheumatoid arthritis: Is a chronic systemic inflammatory autoimmune disease, which targets synovial joints. Synovial joints are the most common and movable joints in the body. The pathological path of rheumatoid arthritis leads to the destruction of articular cartilage and rigidity of the joint and may affect other areas of the body. Unlike osteoarthritis, which occurs primarily at more advanced ages, rheumatoid arthritis can strike at almost any age.
Natural Support for Rheumatoid Arthritis
Gout - a form of Inflammatory Arthritis: Caused by high levels of uric acid (hyperurecemia) and is characterized by the occurence of acute inflammatory arthritis, which is a red, tender and painful swelling of the joint. Dietary yellow flavonoids, especially luteolin and apigenin, appear to display activity of lowering uric acid levels and having a positive effect on gout symptoms. (19, 20)
1. Ishiguro N, et al. [Role of aggrecanase and MMP in cartilage degradation]. Clin Calcium. 2004 Jul;14(7):38-44.
2. Glasson SS, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 31 March 2005. 434, 644-648 .
3. Henrotin Y, et al. Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage. 2010 Feb;18(2):141-9.
4. Buhrmann C, et al. Curcumin mediated suppression of nuclear factor-?B promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther. 2010;12(4):R127.
5. Lay E, et al. Short- and long-term exposure of articular cartilage to curcumin or quercetin inhibits aggrecan loss. J Nutr Biochem. 2011 Mar 16.
6. Koskinen A, et al. Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients. Clin Exp Rheumatol. 2011 Jan-Feb;29(1):57-64
7. Yu ZG, et al. Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Chin Med J (Engl). 2009 Oct 20;122(20):2483-8.
8. Moncada-Pazos A, et al. The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities. J Mol Med (Berl). 2011 Jun;89(6):611-9.
9. Durigova M, et al. Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M. Osteoarthritis Cartilage. 2008 Jan;16(1):98-104.
10. Lim H, et al. Effects of Flavonoids on Matrix Metalloproteinase-13 Expression of Interleukin-1ß-Treated Articular Chondrocytes and Their Cellular Mechanisms: Inhibition of c-Fos/AP-1 and JAK/STAT Signaling Pathways. J Pharmacol Sci. 2011;116(2):221-31.
11. Shin GC, et al. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chem Biol Interact. 2009 Nov 10;182(1):29-36.
12. Pap, T, et al. Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2000;2(5):361-367
13. Abeles AM, et al. The role of the synovial fibroblast in rheumatoid arthritis: cartilage destruction and the regulation of matrix metalloproteinases. Bull NYU Hosp Jt Dis. 2006;64(1-2):20-4.
14. Chang, SK, et al. Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11. Immunol Rev. 2010 Jan;233(1):256-66.
15. Shin GC, et al. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chem Biol Interact. 2009 Nov 10;182(1):29-36
16. Hou Y, et al. Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts. Cell Biol Int. 2009 Feb;33(2):135-47.
17. Park C, et al. Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. Int J Mol Med. 2007 Sep;20(3):365-72.
18. Funk JL, et al. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod. 2006 Mar;69(3):351-5.
19. Mo SF, et al. Hypouricemic action of selected flavonoids in mice: structure-activity relationships. Biol Pharm Bull. 2007 Aug;30(8):1551-6.
20. Flemmig J, et al. Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. Phytomedicine. 2011 May 15;18(7):561-6.