Skin Anti-Aging: Power Support
TETRAHYDROCURCUMIN
• FOXO Transcription Factor Activation. In research animals (mice and fruit flies), tetrahydrocurcumin has significantly increased the lifespan by activating longevity transcription factor FOXO. Transcription factors are proteins which stimulate longevity target genes. Recent tetrahydrocurucmin experiments involving the fruit fly (Drosophila melanogaster) demonstrated significant increases in tolerance to oxidative stress.(1) Authors of the study conclude that “these findings support the idea that oxidative stress may correlate with life-span extension”. The prolific longevity extending properties of tetrahydracurcumin has been demonstrated in several independent studies. (1,2) Although both curcumin and tetrahydrocurcumin both possess strong antioxidant properties, curcumin did not increase tolerance to oxidative stress.
Therefore, tetrahydrocurmin’s effect on longevity is more intricate than simply as acting as an antioxidant. Significantly, in the same study, the longevity effect of tetrahydrocurcumin occurred even under normal, non-stressed conditions.
• Lifespan extension. Tetrahydracurcmin administered to middle aged mice, equivalent to a human in their mid-50s, demonstrated significant increases in mean life span (10% longer) as well as significant increases in the life span of the longest lived mice versus control mice. (2)
• Extremely Strong Antioxidant Activity. As compared to the other curcuminoids derived from curcumin, tetrahydrocurcumin is extremely powerful. Most notably is it’s protective effect against lipid oxidation, which may significantly reduce age accelerating oxidation impact on skin cells.(1)
PTEROSTILBENE
• SIRT Gene Activation. Pterostilbene is considered a calorie restriction mimic, which is known to activate genes associated with longevity (SIRT1). • Pterostilbene. While similar to resveratrol, pterostilbene has greater metabolic stability and boavailability.
• Pterostilbene and Resveratrol. Both improve mitochondrial function and protect against metabolic disease by activating SIRT1 and mimicking calorie restriction.
HYDROXYTYROSOL & TYROSOL (olive polyphenols)
• SIRT Gene Activation. Longevity gene activator.(6)
• Skin UV Radiation Protection (UVA / UVB) (7,8)
• Extends longevity of Skin fibroblasts. Supports longer chronological life span of skin fibroblast cells in dermal layer. Hydroxytyrosol inhibits mitochondrial oxidative stress of dermal fibroblast thereby inhibiting premature senescence of the skin cells. By sustaining a higher number of fibroblasts with age, supports replenishing of extracellular matrix including collagen, elastin and hyaluronic acid. (9)
• TYROSOL - Increases lifespan and Stress Resistance . Tyrosol signifcantly increased the lifespan of laboratory metazoan (c. elegans) by inducing higher resistance to thermal and oxidative stress.(10)
VERBASCOSIDE (Acetoside)(olive polyphenol)
• High Antioxidant Capacity. Verbascoside is a very potent antioxidant, which provided significant life extension using Drosophila melanogaster (fruit fly). (3) Experiments determined a dosage-to-life span correlation. Therefore, increased levels of verbascoside yielded longer life spans
DNA Integrity / Mitochondria Support
VERBASCOSIDE (Acetoside)
• Fast DNA Repair. DNA is easily damaged, and if not quickly repaired, can lead to impaired cellular functionality, accelerated aging, and cancer initiation. Verbascoside is a powerful (4)
• Prevents Mitochondrial Dysfunction. Verbascoside is a potent antioxidant and acts as a scavenger of mitochondrial free radicals. In this capacity, verbascoside helps maintain healthy mitcohondira functioning, which is important in disease prevention and may also support maintenance of skin stem cells and skin renewal.(5)
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REFERENCES:
1. Xiang L, et al. Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor. Aging (Albany NY). 2011 Nov;3(11):1098-109.
2. Kitani K, et al. The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. Biogerontology. 2007 Oct;8(5):567-73.
3. Pan W. et al. Isolation, purification and structure identification of antioxidant compound from the roots of Incarvillea younghusbandii Sprague and its life span prolonging effect in Drosophila melanogaster. Nat Prod Res. 2008 May 20;22(8):719-25.
4. Zheng R, et al. Fast repair of DNA radicals in the earliest stage of carcinogenesis suppresses hallmarks of cancer. RSC Advances Sept. 2011.
5. De Souza P A, et al. Antioxidant activity of natural compounds of Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, by scavenger of mitochondrial reactive oxygen species . Rev. bras. farmacogn. vol.21 no.3 Curitiba May/June 2011
6. Mukherjee S, et al. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med. 2009 Mar 1;46(5):573-8.
7. D’Angelo S, et al. Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radic Biol Med. 2005 Apr 1;38(7):908-19.
8. Guo W, et al. The protective effects of hydroxytyrosol against UVB-induced DNA damage in HaCaT cells. Phytother Res. 2010 Mar;24(3):352-9.
9. Sarsour EH, et al. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2012 Feb;34(1):95-109.
10. Cañuelo A, et al. Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans. Mech Ageing Dev. 2012 Jul 20.
