Hyper - Skin Front Page

REVITALIZING DERMAL SKIN LAYER: HYPER LONGEVITY™

The dermis is the layer of skin immediately below the outermost epidermis layer. Structural support for the skin is provided in the dermis by the extracellular matrix, which provides skin with firmness, fullness and elasticity. The extracellular matrix consists of connective tissue, which is formed by the intertwining of protein fibers (collagen and elastin), as well as hyaluronic acid and other constituents. The extracellular matrix is maintained by fibroblast cells, which synthesizes the components of the matrix, including collagen and elastin fibers.

Aging of the skin results in the collapse of the extracellular matrix. Wrinkles and loss of skin elasticity form as a result of a decay and collapse of the matrix. Dermal structure collapses as a result of lost of fibroblast cells (which renew the matrix), loss and damage of collagen and elastin fibers, loss of hyaluronic acid and other matrix material.

HYPER LONGEVITY™

• Strengthens the Dermal Layer of Skin

o Promotes longevity of dermal fibroblast cells by attenuating effects of UV radiation and oxidative stress. Attenuates lipid peroxidation of skin cells.(1,2,5)
o Protects skin cells from premature senescence by repairing DNA damaged by oxidative stress.(3)
o Prolongs replication capability (chronological age) of skin fibroblasts.(4)
o Increased number and viability of fibroblasts support higher levels of collagen and hyaluronic acid in extracellular matrix .(1,2,5)
o KEY INGREDIENTS: Verbascoside, Hydroxytyrosol, Tetrahydrocurcumin

• Inhibits Collagen Protein Damage in Dermis by UVA Radiation / Glycation

o Oxidative stress plays the major role in UVA damage to the dermis.(1,2)
o Glycated sugar damage to collagen is attenuated.(6)
o KEY INGREDIENTS: Verascoside, Hydroxytyrosol, Tetrahydrocurcumin

• Stimulates New Collagen and Hyaluronic acid production

o Alpha Lipoic Acid stimulates the synthesis of new collagen by the fibroblast cells.(7)
o Hydrolyzed collagen increases levels of proline-hydroxyproline, which stimulates new hyaluronic acid production by fibroblast cells.(8)
o Pterostilbene increases levels of PPARalpha, which promotes the synthesis of new hyaluronic acid production by fibroblast cells.(9)
o KEY INGREDIENTS: BioCell Collagen®  (Hydrolyzed Collagen, Hyaluronic Acid), Alpha Lipoic Acid, Pterostilbene

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REFERENCES:

1. Kostyuk V, et al. Plant polyphenols (Verbascoside) against UV-C-induced cellular death. Planta Med. 2008 Apr;74(5):509-14.

2. Pastore S, et al. Plant polyphenols effectively protect HaCaT cells from ultraviolet C-triggered necrosis and suppress inflammatory chemokine expression. Ann N Y Acad Sci. 2009 Aug;1171:305-13.

3. Zheng R, et al. Fast repair of DNA radicals in the earliest stage of carcinogenesis suppresses hallmarks of cancer. RSC Advances. Sept. 2011.

4. Sarsour EH, et al. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2012 Feb;34(1):95-109.

5. Somparn P, et al. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull. 2007 Jan;30(1):74-8.

6. Pari L, et al. Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes. Fundam Clin Pharmacol. 2007 Dec;21(6):665-71.

7. Tsuji-Naito K, et al. α-Lipoic acid induces collagen biosynthesis involving prolyl hydroxylase expression via activation of TGF-β-Smad signaling in human dermal fibroblasts. Connect Tissue Res. 2010 Oct;51(5):378-87.

8. Ohara H, et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol. 2010 Apr;37(4):330-8.

9. Yamane T, et al. Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan synthase 2 transcripts through an AMP-activated protein kinase/peroxisome proliferator-activated receptor-α-dependent pathway in human dermal fibroblasts.Biochem Biophys Res Commun. 2011 Nov 18;415(2):235-8.

REFERENCES:

(1) Noordam R, et al. High serum glucose levels are associated with a higher perceived age. Age (Dordr). 2011 Nov 20.

(2) D'Angelo S, et al. Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radic Biol Med. 2005 Apr 1;38(7):908-19.

(3) Guo W, et al. The protective effects of hydroxytyrosol against UVB-induced DNA damage in HaCaT cells. Phytother Res. 2010 Mar;24(3):352-9.

(4) Pastore S, et al. Plant polyphenols effectively protect HaCaT cells from ultraviolet C-triggered necrosis and suppress inflammatory chemokine expression. Ann N Y Acad Sci. 2009 Aug;1171:305-13.

(5) Danby FW. Nutrition and aging skin: sugar and glycation. Clin Dermatol. 2010 Jul-Aug;28(4):409-11.

(6) Manickam M, et al. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod. 1997 Jun;60(6):609-10.

(7) Hsu CL, et al. Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Food Funct. 2011 Nov 18.

(8) Thirunavukkarasu V, et al. Lipoic acid improves glucose utilisation and prevents protein glycation and AGE formation. Pharmazie. 2005 Oct;60(10):772-5.

(9) Thirunavukkarasu V, et al. Fructose diet-induced skin collagen abnormalities are prevented by lipoic acid. Exp Diabesity Res. 2004 Oct-Dec;5(4):237-44.

(10) Mukherjee S, et al. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med. 2009 Mar 1;46(5):573-8.

(11) Sarsour EH, et al. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2011 Mar 8.

(12) Park HY, et al. A long-standing hyperglycaemic condition impairs skin barrier by accelerating skin ageing process. Exp Dermatol. 2011 Dec;20(12):969-74.

(13)  Janszky I, et al. Metabolic syndrome in Poland - the PONS Study. Ann Agric Environ Med. 2011 Dec;18(2):270-2.

(14) Akase T, et al. Aging-like skin changes induced by ultraviolet irradiation in an animal model of metabolic syndrome. Biol Res Nurs. 2012 Apr;14(2):180-7. doi: 10.1177/1099800411401013.

(15) Sapwarobol S, et al. Postprandial blood glucose response to grape seed extract in healthy participants: A pilot study. Pharmacogn Mag. 2012 Jul;8(31):192-6.