HYPER LONGEVITY™ Promoting Healthy and Beautiful Skin
ALPHA LIPOIC ACID (ALA) AND PTEROSTILBENE
Age Reversing Antioxidants and Support for Extracellular Matrix. ALA and pterostilbene are important lipid antioxidants which provide protection of the skin cell against destructuve free radicals. Additionally, ALA also contributes to replenishing the dermal extracellular layer, by increasing synthesis of collagen. Pterostilbene adds the moisture locking and skin plumping hyaluronic acid to the dermal layer. Together, ALA and ptersotilbene contribute to maintaining radiant skin even with advancing age. 
• Alpha Lipoic Acid
• Increases Synthesis of Collagen by Human Dermal Fibroblasts. ALA promotes an increase in collagen synthesis in the extracellular matrix by dermal fibroblast cells. Collagen is the primary supporting protein fiber in the dermis. Replenishing collagen in the dermal layer helps prevent wrinkles and maintains younger looking skin.(1) .
• As a Network Antioxidant, Reduces Signs of Skin Aging. . ALA is part of an antioxidant network and acts as a “regenerating antioxidant”. ALA acts to regenerate other antioxidants once they have depleted their antioxidant capacity. Signs of skin aging are significantly reduced by the actions of ALA and other antioxidants in the network. (2) ALA also inhibits the effects free radical damage due to UV photoaging. (3) .
• Improves Skin Appearance and Softness . As a powerful anti-aging antioxidant (having both antioxidant and anti-inflammatory properties), ALA has shown improvement of skin appearance and texture. Oral supplementation to lab animals has been shown an increase in alpha lipoic activity in the skin, as well as decrease in lipid oxidation of the skin.(4).
• Inhibits Damage to Fibroblasts by Radiation. In experimental research, fibroblasts exposed to gamma radiation (similar to that used in cancer radiation treatment), experienced significant increases in free radicals and lipid oxidation. Fibroblasts also experienced significant decreases in antioxidants within the cells. Administration of ALA not only decreased the free radicals generated by the radiation, but also increased levels of depleted antioxidants. (5)
• Pterostilbene
• SIRT1 Anti-Aging Gene Expression.
As with resveratrol,pterostilbene is a SIRT1 gene stimulator. Furthermore, pterostilbene synergistically performs with other gene activators including Tetrahydrocurucmin (there is a synergy between SIRT1 and FOXO gene expression). Increases in SIRT1 can increase levels of FOXO.
• Lipid Antioxidant | Anti-Inflammatory in Skin cells | Anti-Cancer.
High biological activity and greater protection of lipid biological structures in the body, including the skin cell lipid membranes.(6) Lab studies also indicate that pterostilbene may inhibit many types of cancers, including skin, breast and colon cancer. A significant mechanism behind the anti-cancer effect of pterostilbene is the ability to increase expression of Argonaute2 (Ago2), which further increases tumor-suppressive molecules. Perhaps most significantly, is the Ago2-dependent anti-cancer activity known as long-term gene silencing response. This is a powerful anti-cancer action invoked by pterostilbene.(10) In the skin, pterostilbene exhibits powerful anti-inflammatory effect, which has been shown to significantly inhibit experimentally induced skin carcinogenesis.(11)
• Increases Hyaluronic Acid Content in Human Dermal Fibroblasts.
a. Increases PPARalpha Expression. PPARs (peroxisome proliferator-activated receptor) facilitate skin health and healing. In particular PPARalpha, which is increased by pterostilbene, and promotes skin healing after injury-induced inflammation. Increases in PPARalpha also produce increases in hyaluronic acid production.(7)
b. Increases levels of Adiponectin. Pterostilbene also significantly up-regulated the gene expression of adiponectin as well as down-regulated the gene expressions of leptin, resistin. Adiponectin plays a active role in the health of the skin, increasing the synthesis of hyaluraonic acid, via PPARalpha pathway activation. which supports moisture retention and maintaining youthful appearance. (8.9)
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REFERENCES:
(1) Tsuji-Naito K, et al. α-Lipoic acid induces collagen biosynthesis involving prolyl hydroxylase expression via activation of TGF-β-Smad signaling in human dermal fibroblasts. Connect Tissue Res. 2010 Oct;51(5):378-87.
(2) Puizina-Ivic N. Skin aging. Acta Dermatovenerol Alp Panonica Adriat. 2008 Jun;17(2):47-54.
(3) Morganti P, et al. Role of topical and nutritional supplement to modify the oxidative stress. Int J Cosmet Sci. 2002 Dec;24(6):331-9.
(4) Kim MY, et al. Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats. Nutr Res Pract. 2011 Oct;5(5):421-8.
(5) Davis DG, et al. Radioprotective effect of DL-alpha-lipoic acid on mice skin fibroblasts. Cell Biol Toxicol. 2009 Aug;25(4):331-40.
(6) Cichocki M, et al. Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis.
(7) Yessoufou A, et al. Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels. Swiss Med Wkly. 2010 Sep 15;140:w13071. doi: 10.4414/smw.2010.13071.
(8) Hsu CL, et al. Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Food Funct. 2012 Jan 4;3(1):49-57.
(9) Yamane T, et al. Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan synthase 2 transcripts through an AMP-activated protein kinase/peroxisome proliferator-activated receptor-α-dependent pathway in human dermal fibroblasts. Biochem Biophys Res Commun. 2011 Nov 18;415(2):235-8.
(10) Hagiwara K, et al. Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity. Sci Rep. 2012;2:314.
(11) Tsai ML, et al. Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis. Food Funct. 2012 Jul 30.
