Curcumin and Skin Rejuvenation
Promotes more youthful, supple and radiant skin
In India, women are frequently complemented on how beautiful their skin looks even as they get older. When asked what they attribute such youthful skin to, they always respond that it is the curcumin containing foods which they regularly consume. Scientific research is now revealing the underlying mechanisms of curcumin which keep skin so beautiful and younger looking.
• Beautiful and healthy skin is optimized, and aging is reversed, when inflammatory processes in the body are controlled. Conversely, aging is greatly accelerated in the body by increased levels of inflammation. Skin aging, brain aging, cardiovascular aging are all significantly affected by inflammation. Furthermore, inflammation in the body is central to every disease process in the body. Both contributing to the disease and being increased as a result of the disease.
HYPER LONGEVITY™ is effective for inhibiting inflammation, which is one of the mechanisms through which it promotes healthy skin and joints. However, for those wanting further anti-aging support, curcumin (aka “Indian Gold”) provides a second level of defense for countering inflammation through out the body. In addition, curcumin provides an up-lifting feeling, acting as a mood enhancer, by inhibiting the release of glutamate in the brain.(9)
• Curcumin and Inflammatory Skin Diseases:
Curcumin has been shown in lab studies to significanly decrease inflammatory compounds in keratinocytes (the predominant skin cell in the outer epidermis layer). According to the authors of the study, curcumin may be effective in the treatment of inflammatory skin diseases.(1) An earlier study also confirms curcumins anti-inflammatory action in the skin, by the inhibition of NF-KappaB, a powerful gene activator of inflammation.(2) Further research indicates that curcumin may be successful in treatment of psoriasis.(10)
• Curcumin Increases Levels of Adiponectin and Hyaluronic Acid in Skin:
Curcumin increases the production of hormone adiponectin (from fat cells).(7) Adiponectin is very beneficial in supporting overall health, and is becoming evident that it also plays an active role in skin anti-aging. Adiponectin promotes the synthesis of hyaluronic acid in human fibroblast cells, and may play an important role in maintaining skin moisture and youthfulness.(8)
• Curcumin as a Skin Protector and Anti-Aging Agent:
Curcumin also offers significant skin protection and anti-aging by neutralizing free radicals in the skin cells. Furthermore, curcumin accelerates wound healing time by facilitating collagen deposition and improving fibroblast and vascular density in the extra-cellular matrix. (2) In a research article, curcumin is listed as an important natural bioactive compound that contributes to more glowing, healthier and younger looking skin.(3) An ideal adjunct for skin care, curcumin is also superior as a modulator of abnormal skin cell growth, and inhibits the accumulation of age-related pigments.(4) Curcumin also reduces insulin resistance, thereby increasing the uptake of glucose by cells. By lowering blood glucose levels, there is less potential for glucose induced skin aging. Moreover, curcumin has been shown to enhance the health of the beta-cells of the pancreas (which secret insulin) and suppress prediabetes from developing into type 2 diabetes.(13) Importantly, curcumin, which has therapeutic action against prediabetes (metabolic syndrome) may also reduce the harmful effects of UV radiation on the skin, which is signifcantly intensified in individuals with metabolic syndrome.(14.15)
• Curcumin and Increasing LifeSpan: The role of Autophagy and SOD (Superoxide Dismutase)
Autophagy is the process in which the cell performs self-destruction of its internal components. In the normal functioning of the cell, autophagy is a tightly controlled process during the growth, development and homeostasis. Cellular autophagy (also known as "self-eating") is closely linked to longevity, since the ability of a cell to repair and renew is an integral component of longevity. In research studies (using animal models), curcumin was been shown to increase both autophagy and lifespan. In fact AUTOPHAGY and LIFE EXTENSION share involvement of the same anti-aging genes and transcription factors, including SirTs and FoxOs.(6,11) Additional studies indicate that curcumin also increases lifespan by increasing gene expression of SOD, a critical antioxidant enzyme.(12)
(1) Yang ZS, et al. Effect of curcumin on IL-17-induced nitric oxide production and expression of iNOS in human keratinocytes. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Sep;27(9):959-61.
(2) Thangapazham RL, et al. Beneficial role of curcumin in skin diseases. Adv Exp Med Biol. 2007;595:343-57.
(3) Mukherjee PK, et al. Bioactive compounds from natural resources against skin aging. Phytomedicine. 2011 Dec 15;19(1):64-73.
(4) Heng MC. Curcumin targeted signaling pathways: basis for anti-photoaging and anti-carcinogenic therapy. Int J Dermatol. 2010 Jun;49(6):608-22.
(5) Deng YT, et al. Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells. J Agric Food Chem. 2011 Dec 20.
(6) Petrovski G, et al. Does autophagy take a front seat in lifespan extension?J Cell Mol Med. 2010 Nov;14(11):2543-51. doi: 10.1111/j.1582-4934.2010.01196.x.
(7) Shehzad A, et al. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases.Eur J Nutr. 2011 Apr;50(3):151-61.
(8) Yamane T, et al. Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan synthase 2 transcripts through an AMP-activated protein kinase/peroxisome proliferator-activated receptor-α-dependent pathway in human dermal fibroblasts.Biochem Biophys Res Commun. 2011 Nov 18;415(2):235-8.
(9) Lin TY, et al. Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: possible relevance to its antidepressant mechanism.Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1785-93.
(10) Sun J, et al. Curcumin induces apoptosis in tumor necrosis factor-alpha-treated HaCaT cells. Int Immunopharmacol. 2012 Apr 9.
(11) Pallauf K, et al. Autophagy, polyphenols and healthy ageing. Ageing Res Rev. 2012 Apr 6.
(12) Shen LR, et al. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. Age (Dordr). 2012 Jun 1.
(13) Chuengsamarn S, et al. Curcumin Extract for Prevention of Type 2 Diabetes. Diabetes Care. 2012 Jul 6.
(14) Pérez-Torres I, et al. Hibiscus Sabdariffa Linnaeus (Malvaceae), curcumin and resveratrol as alternative medicinal agents against metabolic syndrome. Cardiovasc Hematol Agents Med Chem. 2012 Jun 20.
(15) Akase T, et al. Aging-like skin changes induced by ultraviolet irradiation in an animal model of metabolic syndrome. Biol Res Nurs. 2012 Apr;14(2):180-7. doi: 10.1177/1099800411401013.