Curcumin & Cardiovascular Health

CURCUMIN (BCM-95® - Very High Absorb | Retention)        REFERENCES

Curcumin provides extensive coverage for the strengthening and protection of the cardiovascular system. The prolific nature of curcumin’s benefits extend anti-aging effects to the vascular system, helping to ameliorate pathological changes to the arteries, including the initiation and progression of atheroscleosis. Curcumin also helps protect the heart and laboratory studies suggest that curcumin may lessen the potential for cardiac hypertrophy and heart failure.(13)  Furthermore curcumin possesses anti-thrombotic properties, which helps in the prevention of abnormal platelet aggregation and possible clot formation. 


Until recently, using curcumin as a dietary supplement has been problematic due to its low bioavailability. Curcumin extract is very poorly absorbed by the body, which minimizes its potential usefulness and effectiveness. However, advances in research now provide a next generation form of curcumin, which is both highly absorbed and maintained by the body. BCM-95® curcumin is a special curcuminoid complex which circumvents these problems by delivering maximum absorption (7X’s more absorption) with longer retention (4 hours more) in the blood stream as compared to normal curcumin 95% extract. (16)


Cardiovascular Research Benefits:

 Cardiovascular Anti-Aging: Lowering Key Aging Risk Factors  

Inflammation and C-Reactive Protein:


Healthy Endothelium & Vascular Functioning


o  Oxidative Stress Induced Dysfunction. Laboratory animals administered an endotoxin (a substance which elicits a strong inflammatory response by the immune system and increased levels of oxidative stress), experienced impairment to the vascular system, including the heart and vascular responsiveness. Curcumin (administered both before and after the toxin), both prevented the on-set of dysfunction, and also provided therapeutic normalization.(22)

o  High Glucose Induced Dysfunction. High glucose levels (which are especially seen in diabetics and pre-diabetics), result in an endothelial vasodilation dysfunction. When curcumin was incubated together with  high glucose medium, vascular dysfunction showed reversal.(23)

o  Increases Secretion of Adiponectin by Adipocyte (Fat) Tissue | Aids in Protection of the Endothelium from Dysfunction. Adiponectin is a protein which is secreted only by adipose tissue. Involved in metabolic processes in the body, adiponenctin is thought to play important roles in lipid metabolism and cardiovascular disease.(24) Adiponectin is considered as being anti-diabetic and anti-atherogenic.(25) Among the metabolic actions of adiponectin  includes aiding in glucose uptake (enhancing insulin sensitivity), the clearing of triglycerides from the bloodstream, lowering LDL, increasing HDL levels and protection of  the vascular endothelium against dysfunction. Research studies show that curcumin both increases adiponectin secretion, and also decreases levels of inflammatory interleukin-6 (IL-6) secretion.(26)

Inhibition of Cardio Hypertrophy and Heart Failure


In each of these instances, curcumin was able to block an increase in the thickness of the myocardial wall, and decreases in systolic functioning.(28) Authors of the study conclude that “inhibition of p300 HAT activity by the nontoxic dietary compound curcumin may provide a novel therapeutic strategy for heart failure in humans.



Cardioprotective via Altered Gene Expression in Myocardial Infarction




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