Well being and Feeling Good
Regaining the feeling of being in a good mood. Not overreacting to the surrounding stress or anticipation of stress and overcoming the feeling of depression. Anxiousness, depression and stress are all problems in the modern world. The fast paced lifestyle gives us an inevitable feeling of dread, and fearfulness of what may happen in our lives. For example, panic attacks, the feeling of being so over whelmed by circumstances that we lose our ability to function, are more common today than ever. Furthermore many things which do happen in our lives leave us with a feeling of depression which makes enjoying life even more difficult. We tend to lose our motivation and many times are fearful of advancing ourselves because of anxiety associated with potential “what may happen if I do”.
While some anxiety and depression may be warranted at times, most often anxiety and depression take control of our lives and prevents us from full enjoyment of life experiences and adventures. Not only can anxiousness and depression leave us mentally debilitated, but also the resulting stress can have very real negative physical effects, which can lead to disease and accelerated aging. Regaining the motivation to live life is essential to actually enjoying life.
Natural Support for the Feeling of Well Being
Among nature’s most significant anti-anxiety and anti-depressive compounds are the yellow flavonoids. Apigenin(1), fisetin(2,8), luteolin(3) and quercetin(4) have been shown to exhibit an anxiolytic and anti-depressive effects in laboratory studies. Anxiolytic is another term used in the scientific community for anti-anxiety. Furthermore, curcumin has also been shown to possess anti-anxiety activity, by inhibiting glutamate release in the brain.(7)
In addition to the natural yellow phyto extracts, “pterostilbene was investigated in a classic animal model of anxiety and found to be comparable in activity to the anti-anxiety drug diazepam used as the control drug in the model.” Studies on pterostilbene were conducted at the University of Mississippi pharmacy department “determined pterostilbene activates the ERK signaling pathway in the hippocampus, an area of the brain speculated to play a role in anxiety.” In fact exclusive worldwide patent rights have been granted by the University of Mississippi to the ChromaDex Corp, (the makers of PteroPure® pterostilbene – also found in Yellow Longevity), for therapeutic uses of pterostilbene as an anti-anxiety agent.(6)
(1) Suresh K, et al. Apigenin: The Anxiolytic Constituent of Turnera aphrodisiaca. 2006, Vol. 44, No. 2 , Pages 84-90
(2) Maher P, et al. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One. 2011;6(6):e21226.
(3) Ishisaka M, et al. Luteolin Shows an Antidepressant-Like Effect via Suppressing Endoplasmic Reticulum Stress.Biol Pharm Bull. 2011;34(9):1481-6.
(4) Bhutada P, et al. Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):955-60.
(5) Gilhotra N, et al. GABAergic and nitriergic modulation by curcumin for its antianxiety-like activity in mice.Brain Res. 2010 Sep 17;1352:167-75.
(6) ChromaDex Corp. Pteropure® Pterostilbene Intellectual Property, June 2011.
(7) Lin TY, et al. Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: possible relevance to its antidepressant mechanism.Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1785-93.
(8) Zhen L, et al. The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system. Behav Brain Res. 2012 Mar 17;228(2):359-66.