QTY 1: $20.95 each
QTY 3: $19.95 each
Gold and Yellows are essential herbs which promote longevity and healthy aging!
Yellow flavonols (including Myricetin and Quercetin) and flavones (including apigenin, luteolin and baicalin) are powerful activators of FOXO.
YELLOW NATURALLY™ also supports muscle maintenance in aging. YELLOW NATURALLY™ is rich in Toll-like receptor 4 (TLR-4) and P38 MAPK inhibitors, which are involved in the inflammatory process. Aging is a factor in increased inflammation. Furthermore, research indicates that TLR-4 is the master switch for muscle catabolism induced by inflammation (1) including the activation of P38 MAPK. In aging active adults, elevation of P38 MAPK is linked to the inability of muscle stem cells to repair injured muscle and ultimately the loss of muscle mass with age. (2-3)
1. Doyle A, et al. Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways. FASEB J. 2011 Jan
2. Bernet JD, et al. p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat Med. 2014 Mar
3. Cosgrove BD, et al. Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.Nat Med. 2014 Mar