Glucoraphanin is found in broccoli, and is a converted in the body to sulforaphane. As a powerful Nrf2 activator, sulforaphane reduces oxidative stress, enhancing the removal of environmental toxins, increasing cellular antioxidant defense and contributing to healthy organ function. In highly polluted areas of China, glucoraphanin / sulforaphane was shown to enhance detoxification of airborne pollutants. Air pollutants (especially the fine particulates), from cars, factories and even smoke in the air, can irritate and inflame the lungs. Consequences of air pollution may include lung cancer and cardiopulmonary disease. Study results of approximately 300 Chinese participants taking a broccoli sprout beverage, rich in glucoraphanin, showed a rapid and sustained urinary excretion of benzene. Benzene is a hydrocarbon, highly toxic and a carcinogenic component of air pollution. In addition, other toxic air pollutants were also found in increased amounts in the urine as compared to the placebo group. Therefore, the ability of glucoraphanin (via sulforaphane and nrf2) to enhance the detoxification of air pollutants is viewed as a potential weapon in cancer prevention in toxic air environments.(2)
(1) Egner PA, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila). 2014 Aug.
(2) Kensler TW, et al. Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Top Curr Chem. 2013;329:163-77.
Cardiovascular health has been concerned with cholesterol. HDL being considered the "good" cholesterol while LDL being the "bad". However, additional factors must be taken into consideration when identifying risk factors.
(1) LDL is classified as to particle size. Small dense LDL poses the greatest threat for the development of atherosclerosis. Large LDL (which are more buoyant), have minimal risk. Most LDL tests do not discern between the two types - specific tests for LDL must be specified.
(2) Inflammation (as indicated by CRP - C-reactive protein) is considered the key factor in the pathogenesis of atherosclerosis. Inflammation injures the arterial wall, which then experience an influx of cholesterol into the site of the injury. Oxidized cholesterol accumulates in the endothelium and causes further damage.
(3) Oxidized LDL receptor (LOX-1) on the endothelium markedly increases the uptake of oxidized cholesterol. Suppression of the LOX-1 receptor greatly decreases cholesterol intake into the arterial wall.
(4) Blood Sugar / Insulin Resistance - higher levels of blood sugar results in increased damage of the endothelium.
Natural support for cardiovascular health:
• Bergamonte® is a citrus extract which supports healthy cholesterol, including increasing HDL and LDL (large particle - considered as healthy) and decreasing small dense LDL (the harmful LDL). Furthermore, Bergamonte® supports lower inflammation (lower CRP), and reduced blood sugar.(1)
• Magnesium is of major importance in cardiovascular health. Benefits of magnesium include reduction of hypertension, atherosclerosis, coronary artery disease, congestive heart failure, and cardiac arrhythmias.(2) Magnesium also reduces CRP levels (3) and improves endothelium tone.
• Curcumin is a multi-faceted cardiovascular health promoter. As a powerful anti-inflammatory, curcumin provides systemic inflammation reduction.(4) Curcumin is also anti-hyperglycemic and enhances insulin sensitivity.(5) Insulin resistance is considered a major risk factor for atherosclerosis.
• Taurine acts as a vasodilator and myocardial protective. (6)
• Vinpocetine plays several significant roles in the inhibition of atherosclerosis. First, it decreases the uptake of cholesterol by reducing the Lox-1 receptor sites (7). Additionally, vinpocetine suppresses the pathological changes in the artery which include proliferation of vascular smooth muscle (8) and inhibits NFKappa-B arterial inflammation.(9,10)
(1) HP Ingredients Bergamonte® Research. 2015.
(3) Dibaba DT, et al. Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review. Eur J Clin Nutr. 2014 Apr
(4) He Y, et al. Curcumin, Inflammation, and Chronic Diseases: How Are They Linked? Molecules. May 2015.
(5) Ghorbani Z, et al. Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin. Int J Endocrinol Metab.2014 Oct.
(6) Karabacak K, et al. Effects of taurine on contractions of human internal mammary artery: a potassium channel opening action. Eur Rev Med Pharmacol Sci, 2015 Apr.
(7) Cai Y, et al. Vinpocetine attenuates lipid accumulation and atherosclerosis formation. Biochem Biophys Res Commun. 2013 May.
(9) Jeon KI, et al. Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism, Proc Natl Acad Sci USA 2010 May.
(10) Zhuang J, et al.Inhibitory effects of vinpocetine on the progression of atherosclerosis are mediated by Akt/NF-êB dependent mechanisms in apoE-/- mice. PloS One. 2013 Dec.
Wild crafted berries are grown and harvested in the wild. In contrast to cultivated berries, which use significant amounts of pesticides, wild berries do not use pesticides. As such it is a much healthier choice for those wishing to gain the benefit of berries without the toxic buildup of pesticides in the body. Furthermore, wild crafted berries have been shown to have higher amounts of anti-aging anthocyanins, the dark colored pigments in berries associated with supporting brain, cardiovascular and general body health.
Wild blueberry species were shown to have potent anti-inflammatory action, by inhibiting NFKappaB activation, and thereby inhibiting the production of inflammatory cytokines.(1,2)
We use only wildcrafted berries in all of our formulas. Wildcrafted blueberries are harvested from Alaska, while bilberry, lingonberry, blackberry. black currant and chokeberry are grown in the wilds without pesticides from Sweden. BLUE NATURALLY™ & PURPLE LONGEVITY® have the full mixed complex of all the different species of wild berry.
Wild crafted berries are also contained in:
(1) Kang J, et al. Phenolic acids of the two major blueberry species in the US Market and their antioxidant and anti-inflammatory activities. Plant Foods Hum Nutr. 2015 Mar.
(2) Taverniti V, et al. Immunomodulatory effect of a wild blueberry anthocyanin-rich extract in human Caco-2 intestinal cells. J Agric Food Chem 2014 Aug
The most visible effect of aging is the breakdown of the collagen rich connective tissue matrix which provides support for the skin. Sulfur, in the form of MSM (methylsulfonylmethane) maintains disulfide bonds that hold collagen strands in strong form and preserve the pliancy of connective tissue. By maintaining healthy collagen, cross-linking or "hardening" of the tissue is inhibited allowing for healthy dermal functioning as well as connective tissue forming the structural basis of the body.(1)
MSM supports longevity of the joint by strengthening connective tissue associated with cartilage, tendons and ligaments. Studies indicate that MSM helps prevent the degeneration of cartilage in the knee, while maintaining the strength of the tendons and ligaments.(2)
Since connective tissue is pivotal for the internal support of organs and blood vessels, MSM can also help maintain the internal support connective tissues.
Further benefits of MSM include increasing plasma levels of glutathione, anti-inflammatory and having a positive effect on autoimmune diseases.
(1) Bergstrom® Nutrition OptiMSM® information on the benefits of MSM. 2015.
(2) Ezaki J, et al.Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab, 2013 Jan,
Quality living meaning enjoying life. Perhaps the most important aspect is the sense of well being. Changes within our body, including increased inflammation in the brain, insulin resistance and stress, especially with aging, can affect the way we perceive ourselves and the world around us. For example, stress related pathways are implicated in depression. The stress response involves an increase in Cortisol (the stress hormone), and inflammatory cytokines which promotes insulin resistance.(1) Furthermore, the stress response is seen as a primary factor in metabolic syndrome. Chronically high cortisol levels is damaging to the body, which accelerates aging. Cortisol especially damages the health of the brain.(2,3)
Many natural gold and yellow ingredients support a healthy cortisol response (by acting as an adoptogen) and also promote reductions in inflammation in the brain and elevate GABA (feel good) neurotransmitters.(4-9)
Mental Well being support IMMORTALITY GOLD™ SERIES.
1. Gold, Phillip, et al. Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress. 2015 Mar 24.
2. Abdanipour A, et al. In vitro study of the long-term cortisol treatment effects on the growth rate and proliferation of the neural stem/precursor cells. Neurol Res. 2015 Feb.
3. Martocchia A, et al. Recent advances in the role of cortisol and metabolic syndrome in age-related degenerative diseases. Aging Clin Exp Res. 2015 Mar 27.
4. Panossian AG. Adaptogens in mental and behavioral disorders. Psychiatr Clin North Am. 2013 Mar.
5. Li J, et al. Effect of Schisandra chinensis on interleukins, glucose metabolism, and pituitary-adrenal and gonadal axis in rats under strenuous swimming exercise. Chin J Integr Med. 2015 Jan.
6. Zhao X, et al. Chronic curcumin treatment normalizes depression-like behaviors in mice with mononeuropathy: involvement of supraspinal serotonergic system and GABAA receptor. Psychopharmacology (Berl). 2014 May.
7. Bhatia N, et al. Adaptogenic potential of curcumin in experimental chronic stress and chronic unpredictable stress-induced memory deficits and alterations in functional homeostasis. J Nat Med. 2011 July.
8. Thakur AK, et al. Protective effects of Andrographis paniculata extract and pure andrographolide against chronic stress-triggered pathologies in rats. Cell Mol Neurobiol. 2014 Nov.
9. De la Pena JB, et al. Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor. Arch Pharm Res. 2014 Feb.
As the world becomes more mobile, electronic devices have become essential in everyday life. However, the LED (Light Emitting Diode) screens of devices, including smartphones, computer screens, tablets and televisions, emit very high levels of blue light. The problem: blue light is very destructive to the retina of the eye, and may contribute to the development of AMD (Age-Related Macular Degeneration). In comparison, blue light produces 100 times more light induced retinal damage versus orange light. Higher levels of lutein and zeaxanthin in the retina, which are very effective in absorbing toxic blue light, can help block this damage. Furthermore, the higher the macular density of these carotenoids the more effective the protection. VISION VITALITY™ contains high levels of lutein (35 mg) and zeaxanthin which promotes significant protection of the retina.
1. Kuse, Y, et al. .Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light. Sci Rep. 2014 Jun 9
2. Chamorro E, et al. Effects of light-emitting diode radiations on human retinal pigment epithelial cells in vitro. Photochem Photobiol. 2013 Mar-Apr.
3. Keyvan Koushan, et al. The role of Lutein in Eye-Related Disease. Nutrients. 2013
There has been a longstanding awareness that amyloid plaques in the brain are a major causative factor in the development of cognitive problems, including Alzheimer's Disease. However, recent research indicates that another major contributing factor in cognition is vascular impairment in the brain.(1) Current research suggests links between heart disease and dementia.(2) In fact, damage to the small blood vessels in the brain may significantly increase risk of cognitive problems with aging.
In recognition of the vascular component, we now offer a new specially priced package for brain health and maintenance which addresses both areas of concern. The new product is called NEURO PERPETUAL™ and combines support for brain protection and healthy blood flow to the brain.
1. de la Torre, JC. Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia. Cardiovasc Psychiatry Neurol.2012.
2. Ferreira LK, Tamashiro-Duran JH, Squarzoni P, et al. The link between cardiovascular risk, Alzheimer’s disease, and mild cognitive impairment: support from recent functional neuroimaging studies. Rev Bras Psiquiatr. 2014 Jun 10.