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Cardiovascular Health -Restoring Arterial Health

Maintaining healthy arteries promotes blood circulation, tissue and organ oxygenation and longer life

VASCULAR VX™ is a next generation vascular support formula, helping to maintain arterial elasticity, and limiting potential for the pathological build-up in the arteries, which is responsible for atherosclerosis.

  • ARONIA BERRY (Polysaccharides) - Ameliorates aging and inflammation in research animals, via beneficial support of anti-aging signaling pathways AMPK/SIRT1/NF-κB and Nrf2/HO-1. Significantly, aronia berry increases levels of beneficial bacteria in the intestine which plays an important anti-aging role. (1)
  • Increases in HDL cholesterol in aging lab animals.(2)
  • Provides comprehensive cardiovascular support. Many studies have shown the efficacy of aronia berry in in vitro and in vivo for cardiovascular health. Indications include beneficial effects on  hypertension, LDL oxidation, lipid peroxidation, total plasma antioxidant capacity and dyslipidemia.(3)
  • SAFFRON -  Studies indicate that saffron may have a anti-atherosclerosis role. Important saffron benefits may include atherosclerosis regression and /or stabilization of atherosclerosis in animal models prone to atherosclerosis.(4)  Also clinical studies show positive effects in support of blood circulation.(5) 
  • ARTICHOKE - Supports healthy lipid levels. Including decreased LDL, total cholesterol, and triglycerides.(6)
  • APIGENIN -  Supports rejuvenation of aging arterial blood vessels. In lab studies, apigenin mitigated age-related vascular inflammation, oxidative stress, and reversed aortic stiffening aging.(7)
  • Further apigenin has been shown to be anti-hypertensive and protective against cardiac hypertrophy. (8)

 VASCULAR VX  (ARONIA BERRY | SAFFRON | ARTICHOKE | APIGENIN)

 

REFERENCES:

(1) Zhao Y, et al. Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.  Sci Rep. 2021 Oct 18

(2) Daskalova E, et al. Black Chokeberry ( Aronia melanocarpa) Functional Beverages Increase HDL-Cholesterol Levels in Aging Rats. Foods. 2021 Jul

(3) Kasprzak-Drozd K, et al. The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases. Int J Mol Sci. 2021 Jun.

(4) Kadoglou N, et al. The cardiovascular-protective properties of saffron and its potential pharmaceutical applications: A critical appraisal of the literature. Phytother Res. 2021 Aug 26.

(5) Xing B, et al. Phytochemistry, pharmacology, and potential clinical applications of saffron: A review  J Ethnopharmacol. 2021 Dec 5.

(6) Santos H, et al. The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacol Res. 2018 Nov

(7) Clayton Z, et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. AM J Physiol Heart Circ Physiol. 2021 Jul 

(8) Gao H, et al. Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus. Cardiovasc Toxicol, 2021 Sept.