CURCUMIN PXC® - The Proteostasis Curcumin® and Fisetin for Longevity

PROTEOSTASIS. Defines the ability of the body to maintain the fidelity of  biogenesis of protein (non-defective proteins), folding. movement, and removal of old protein aggregates. Especially significant is the removal of old damaged protein aggregates, which are detrimental to the functioning of the cell. Clearing old cellular debris, through a process called autophagy, greatly enhances the youthful functioning of the cell. 

CURCUMIN ENHANCES AUTOPHAGY. Lifespan and autophagy are strongly
 associated with one another.  Calorie restriction, resveratrol and curcumin are known to improve autophagy and increase lifespan. In fact, all life extension mechanisms depend upon the importance of autophagy for clearing cellular damage.(1,2)

Aging affects molecular pathways that influence health and longevity. As a result, there is a reduction of cellular debris clearance (autophagy), decreased  the pool of stem cells, increase in inflammation and cellular senescence. 

CURCUMIN has been shown to by positively regulate longevity by through important molecular pathways, including IIS, mTOR and FOXO. Curcumin is a powerful activator of the body's antioxidant defense system, as an Nrf2 activator. As an antioxidant, curcumin stabilizes and protects telomeres. Inflammation is also a powerful promoter of aging. Curcumin inhibits the powerful inflammation transcription factor NF-κB and is associated with reduced levels of inflammation.(3)  PROTEOSTASIS is impacted by all these aging pathways.(4) Therefore, curcumin supports longevity via aging signaling and proteostasis (autophagy).

• NEURODEGENERATION AND AUTOPHAGY.

Misfolded proteins in the brain are associated with poorly functioning autophagy. Autophagy removes aggregate protein accumulations which is responsible for neurodegeneration. Curcumin, research indicates, may help restore autophagy in the brain, to clear these misfolded proteins. (5) Oleuropein, a component of Olive Oil, in addition to curcumin, is implicated in mitophagy in the brain, removing old and dysfunction mitochondria. (6)

• SIRT1 (SIRTUINS) ENHANCES PROTEOSTASIS

SIRT1 is an enzyme which regulates cellular processes relative to longevity. SIRT1 INCREASES PROTEOSTASIS ,which is an important component of the longevity effect. Natural activators of SIRT1 include Curcumin, Fisetin, Quercetin and Resveratrol.(15)

• ATRIAL FIBRILLATION: PROTEOSTASIS AUTOPHAGY & INFLAMMATION

Cardiac remodeling through failure of autophagy, proteostasis and inflammation are believed to be a root cause of atrial fibrillation. Cardiomyocytes are replaced by non-functional proteins..(12. 13)  

• PROTEOSTASIS DECLINE SIGNIFICANTLY IMPACTS AGING. (7)

With age, cells become replicative scenescent - losing ability to produce new cells. Furthermore, scenescent cells are old cells. Old cells have been shown to lose proteostasis, which further limit the abilty of the cell to respond to external threats and maintain function. Curcumin and pterostilbene(11) helps inhibit cellular scenescence. Fisetin and quercetin are considered senolytics, which are capable of removing scenescent cells. (10)  Importantly, recent research also indicates that curcumin also removes scenescent cells.(14)

CURCUMIN PXC® - Incorporates highly bioavailable curcumin  Furthermore, Curcumin PXC also includes powerful supplemental ingredients in support of proteostasis.

• AUTOPHAGIX™ Complex - Rutin, Lonicera japonica (8), Oleuropein, Quercetin. 
• ROSEMARY PROTEOSTASIS™ COMPLEX (9)
• FISETIN (10)
• TRANS-PTEROSTILBENE

CURCUMIN PXC® - THE PROTEOSTASIS CURCUMIN® 

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