New research suggests that miRNA (microRNA) is a new target in the war against prostate cancer. MiRNA are short segments of RNA but are not involved with the coding of protein. However, miRNA does play a role in gene expression, frequently to silence the expression of a gene. In the case of prostate cancer, miRNA silences the expression of a tumor suppression protein, thereby allowing growth of the prostate cancer. Resveratrol and pterostilbene increases expression of the tumor suppression protein by decreasing levels of miRNA, thereby suppressing prostate cancer growth. Authors of the new research suggest that both stilbenes (resveratrol and pterostilbene) as candidates for chemopreventive and therapeutic use in prostate cancer.
(1) Dhar S, et al. Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer. Oncotarget. 2015 Aug 6