New research validates earlier studies that curcumin may play an effective role in improving memory function in amyloid affected brain function. Using a rodent model of Alzheimer's disease (AD), curcumin was shown to reduce levels of amyloid (a characteristic of Alzheimer's Disease) and ameliorate memory deficits. Chronic administration of curcumin improved cognitive functioning through the removal of amyloid and improved functioning of the memory center of the brain (the hippocampus). Curcumin affected two processes in the hippocampus related to memory formation: increasing the protein BDNF (brain derived neurotropic factor) and increasing ERK activation. ERK is an essential process involved with hippocampus learning.
(1) Zhang L, et al. Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway. PLoS One. 2015 Jun.